EMOTION REGULATION AND AFFECTIVE STYLE: NEURAL SUBSTRATES

情绪调节和情感风格：神经基质

• 批准号: 7197278
• 负责人: Richard J Davidson
• 金额: $ 32.73万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7197278
• 关键词: adolescence (12-20); amygdala; anxiety; anxiety disorders; behavioral /social science research tag; cingulate gyrus; clinical research; cortisol; electroencephalography; electrophysiology; emotions; functional magnetic resonance imaging; human subject; mood disorders; neuroanatomy; prefrontal lobe /cortex; psychopathology; social psychology; startle reaction; twin /multiplet

The overarching purpose of this project is to further our understanding of the neural circuitry underlying the regulation of negative affect, with a focus on prefrontal cortex (PFC), anterior cingulate cortex (ACC) and amygdala. Variations in affective style are assumed to be based in large part on variations in the capacity or skill to regulate emotion. A series of functional magnetic resonance imaging (fMRI) studies are proposed to examine basic neural mechanisms of voluntary emotion regulation in response to both emotional picture viewing as well as to a paradigm that elicits anticipatory anxiety. Individual differences in the functional neuroanatomical substrates of emotion regulation will be examined and relations with electrophysiological measures of prefrontal activation asymmetry and with startle probe measures of emotion regulation will be determined. We will also examine the extent to which regulatory skill evidenced in response to phasic stimuli in an acute laboratory paradigm are related to regulation of cortisol in response to the Trier Social Stress Test administered on two occasions. Finally two experiments with samples derived from Project V (adolescents are varying risk for internalizing disorders) and Project IV (MZ and DZ 7-9 year old twin pairs) will be conducted. One of these studies will utilize the same emotion regulation to determine whether adolescents selected to be at risk for internalizing disorders differ in their patterns of PFC, ACC and amygdala activation and other study will continue our psychophysiological analysis of temperament in MZ and DZ twins. The experiments in this project will collectively advance our knowledge of the neural basis and physiological concomitants of affective styles that are associated with vulnerability to psychopathology and will facilitate the early detection of risk for mood and anxiety disorders.

该项目的首要目的是进一步了解负面情绪调节背后的神经回路，重点关注前额叶皮层 (PFC)、前扣带皮层 (ACC) 和杏仁核。情感风格的变化被认为在很大程度上是基于调节情绪的能力或技能的变化。一系列功能性磁共振成像（fMRI）研究旨在检查自愿情绪调节的基本神经机制，以响应情绪图片观看以及引发预期焦虑的范式。将检查情绪调节的功能性神经解剖学基础的个体差异以及与电生理学的关系 将确定前额叶激活不对称性的测量和惊吓探针情绪调节的测量。我们还将研究在急性实验室范式中对阶段性刺激的反应所证明的调节技能与对两次进行的特里尔社会压力测试的皮质醇调节的相关程度。最后，将使用来自项目 V（青少年具有不同的内化障碍风险）和项目 IV（MZ 和 DZ 7-9 岁双胞胎）的样本进行两项实验。其中一项研究将利用相同的情绪调节来确定被选为有内化障碍风险的青少年的 PFC、ACC 和杏仁核激活模式是否不同 其他研究将继续我们对同卵双胞胎和同卵双胞胎的气质进行心理生理学分析。该项目中的实验将共同推进我们对与精神病理学脆弱性相关的情感风格的神经基础和生理伴随物的了解，并将有助于及早发现情绪和焦虑障碍的风险。