MULTISCALE MODELS FOR PACKAGING VIRAL DNAS

用于包装病毒 DNA 的多尺度模型

• 批准号: 7358854
• 负责人: STEPHEN C. HARVEY
• 金额: $ 1.1万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358854
• 关键词: MULTISCALE; MODELS; PACKAGING; VIRAL; DNAS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are continuing our investigation of the packaging of double-stranded DNA into viral capsids, with particular emphasis on bacteriophage. The studies use a reduced representation model with one pseudoatom for every ten basepairs (original model), or one pseudoatom for every six basepairs (revised model). The goal is to understand the structural, kinetic, and thermodynamics of DNA packaging into viruses.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。我们正在继续研究将双链 DNA 包装到病毒衣壳中，特别是噬菌体。这些研究使用简化表示模型，每十个碱基对有一个假原子（原始模型），或每六个碱基对有一个假原子（修订模型）。目标是了解 DNA 包装到病毒中的结构、动力学和热力学。