X-Ray Detector for the Life Sciences CAT at the APS

APS 生命科学 CAT 的 X 射线探测器

• 批准号: 6877407
• 负责人: WAYNE F ANDERSON
• 金额: $ 50万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877407
• 关键词: biomedical equipment purchase; computed axial tomography; electron crystallography; structural biology

DESCRIPTION (provided by applicant): This proposal requests funds for acquiring state of the art instrumentation for structural biology research on the initial insertion device beamline in the Life Sciences (LS-CAT) sector at the Advanced Photon Source. This beamline will utilize radiation from the first of two (2) undulators that LS-CAT will install and will provide a tunable, high intensity beamline for macromolecular crystallography. Funds for the Phase I construction, which includes this beamline, have already been obtained by LS-CAT and construction is about to begin. It is expected that first use of the beamline will occur in late 2005. The Life Sciences Collaborative Access Team is a consortium of academic and research institutions comprised of Northwestern University, Michigan State University, the University of Michigan, Wayne State University, the Van Andel Institute, the University of Illinois at Urbana-Champaign, and the University of Wisconsin. The investigators participating in LS-CAT are involved in cutting edge structural biology with special emphasis in membrane proteins, multicomponent systems in signaling and protein transport, protein-nucleic acid complexes involved in genome replication, repair, recombination and regulation, and enzymes that are novel targets for mechanistic studies or biotechnology. Many of the researchers associated with LS-CAT have already reached the technical barriers of small crystal size or large unit cells that make access to a dedicated synchrotron source essential to the scientific progress. The instrumentation requested is a large area CCD detector suitable for high resolution studies of individual macromolecules and complexes with large unit cells. The requested detector will have the large surface area, high spatial resolution and rapid read-out that are essential for allowing investigators to tackle increasingly difficult structural problems.

描述（由申请人提供）：该提案要求提供资金，用于购买最先进的仪器，用于先进光子源生命科学（LS-CAT）部门初始插入装置光束线的结构生物学研究。该光束线将利用 LS-CAT 将安装的两 (2) 个波荡器中第一个的辐射，并为大分子晶体学提供可调谐的高强度光束线。包括这条光束线在内的一期建设资金已由LS-CAT获得，施工即将开始。预计光束线将于 2005 年底首次使用。生命科学协作访问团队是一个由西北大学、密歇根州立大学、密歇根大学、韦恩州立大学、范安德尔学院组成的学术和研究机构联盟。研究所、伊利诺伊大学厄巴纳-香槟分校和威斯康星大学。参与 LS-CAT 的研究人员涉及尖端结构生物学，特别侧重于膜蛋白、信号传导和蛋白质运输的多组分系统、参与基因组复制、修复、重组和调节的蛋白质-核酸复合物以及新颖的酶机械研究或生物技术的目标。许多与 LS-CAT 相关的研究人员已经突破了小晶体尺寸或大晶胞的技术障碍，这使得获得专用同步加速器源对于科学进步至关重要。所需仪器是大面积 CCD 探测器，适用于单个大分子和具有大晶胞的复合物的高分辨率研究。所需的探测器将具有大表面积、高空间分辨率和快速读数，这对于研究人员解决日益困难的结构问题至关重要。