GERMPLASM & PHYTOCHEMICAL PROFILING/NIKOLAU, BASIL

种质质

• 批准号: 7293904
• 负责人: DIANE F BIRTH
• 金额: $ 24.77万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7293904
• 关键词: Biochemical; Biochemical Genetics; Botanicals; Characteristics; Chemicals; Clinical Trials; Collection; Communities; Condition; Controlled Environment; Cues; Data; Data Collection; Databases; Development; Echinacea (Asteraceae); Echinacea Preparation; Environment; Fingerprint; Health Benefit; Human; Hypericum; Information Networks; Information Resources; Internet; Iowa; Laboratory Research; Lead; Medicinal Plants; Methods; Ocimum basilicum; Phytochemical; Plants; Population; Production; Prunella (angiosperm); Range; Recommendation; Research; Research Personnel; Research Project Grants; Risk; Role; Seeds; Sorting - Cell Movement; Source; Support of Research; Surveys; System; Universities; Variant; design; dietary supplements; improved; metabolomics; plant growth/development; tool

Core A of the Iowa Center for Botanical Supplement Research has five long-term objectives in support of the research being conducted within the Center to improve our understanding of the human health benefits and potential risks of the dietary supplements, Echinacea, Hypericum, and Prunella. First, we will expand comprehensive plant germplasm collections of Echinacea and Hypericum, and develop collections of Prunella, in a manner designed to represent a broad range of taxonomic,genetic and biochemical diversity, and to propagate the plants through control-pollinated seed production and vegetative means. In this way, these well-documented and characterized plant collections will be made available for research by Center investigators and the broader research community. Second, we will actively curate these medicinal plant germplasm collections at the North Central Regional Plant Introduction Station (NCRPIS) as part of the US National Plant Germplasm System, along with all data associated with their origins, taxonomic identities, and biochemical characteristics, which will be made available via the Internet in the Germplasm Resources Information Network (GRIN) database. Third, we will produce vegetative materials of known-source populations of these plants under controlled conditions at the NCRPIS, through both field and controlled-environment culture, to serve as well- characterized plant materials for the Center's research projects. Fourth, we will conduct fingerprint analyses and chemical identification of the phytochemicals found in these plants by conducting analytical research at Iowa State University's W.M. Keck Metabolomics Research Laboratory. And finally, we will survey the effects of environmental and developmental cues on the phytochemical fingerprints of germplasm collections of Echinacea, Hypericum, Prunella, focusing on Prunella, where little is known about the roles of environment and plant development on its chemical profiles. These core activities provide valuable tools that allow researchers, who study the bioactive and toxic components of these botanical supplements, methods for sorting out variation among plant species and populations being used as sources for these supplements. This has been a complicating factor in the study of all botanical supplements. By using known-source materials that are well characterized biochemically, Center researchers can more efficiently identify bioactive components, and make recommendations that lead to better clinical trials to maximize the human health benefits from these supplements while minimizing risks to consumers.

爱荷华州植物补充研究中心的核心A具有五个长期目标，以支持 中心内进行的研究是为了提高我们对人类健康益处的理解和 饮食补充剂，紫锥菊，金丝桃木和蛋黄的潜在风险。 首先，我们将扩大紫锥菊和金丝桃木的全面植物种质收集，并发展 Prunella的集合，旨在代表广泛的分类学，遗传和 生化多样性，并通过控制 - 授粉的种子生产和营养来传播植物 方法。这样，这些有据可查的植物收集将可用于 中心研究人员和更广泛的研究社区的研究。 其次，我们将积极策划这些药用植物的种质收集 植物引言站（NCRPI）作为美国国家植物种质系统的一部分，以及所有数据 与它们的起源，分类学身份和生化特征相关联 通过Internet在“种质资源信息网络（GRIN）数据库中获得”。 第三，我们将生产这些植物的已知源种群的营养材料 NCRPIS的条件，通过田间和受控环境文化，可以很好地发挥作用 为该中心的研究项目表征了植物材料。 第四，我们将对这些发现的植物化学物质进行指纹分析和化学鉴定 通过在爱荷华州立大学的W.M.进行分析研究通过分析研究凯克代谢组学研究 实验室。 最后，我们将调查环境和发展线索对植物化学的影响 紫锥菊，金丝桃，prunella的种质收集的指纹，专注于Prunella，几乎没有 关于环境和植物发育在其化学轮廓上的作用。 这些核心活动提供了有价值的工具，可以使研究人员（研究生物活性和有毒的研究人员） 这些植物补充剂的组成部分，用于整理植物物种之间变化的方法 种群被用作这些补充剂的来源。这是研究中的复杂因素 在所有植物补充剂中。通过使用具有生化特征良好特征的已知源材料， 中心研究人员可以更有效地识别生物活性成分，并提出领导的建议 更好的临床试验以最大程度地利用这些补充剂的人类健康益处，同时最大程度地降低风险 给消费者。