Dosimetry

剂量测定

• 批准号: 7728854
• 负责人: Robert M Sharkey
• 金额: $ 5.27万
• 依托单位: CTR FOR MOLECULAR MEDICINE/IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7728854
• 关键词: All Sites; Calibration; Case Report Form; Clinical Protocols; Clinical Trials; Core Facility; Data; Discipline of Nuclear Medicine; Drug Kinetics; Ensure; Equipment; Evaluation; Extramural Activities; Health; Image; Medical Records; Methodology; Nuclear; Nuclear Physics; Numbers; Organ; Patients; Physicians; Procedures; Process; Protocols documentation; Purpose; Qualifying; Radiation; Radioactivity; Radioimmunoconjugate; Reporting; Research Personnel; Services; Site; Specific qualifier value; Standards of Weights and Measures; Time; Training; Work; animal data; digital; dosimetry; interest; pre-clinical; programs; quality assurance; residence; tumor

The Dosimetry Core has been established at CMMI for about 6 years. The purpose of this core was to develop standard procedures for processing pharmacokinetic and dosimetry data for CMMI-sponsored clinical trials, but this core also assists investigators at CMMI in preclinical evaluation. The core is responsible for first training sites in the methodology that CMMI requires of its imaging protocols and ensures all equipment, both internally and at extramural sites, are properly calibrated and maintained. The core receives digital and hard copies of all imaging studies performed by investigational sites for CMMI clinical protocols. The core will then reviews these images and prepares regions of interest from which time-activity curves can be generated. A trained nuclear physician and a nuclear medicine technologist supervise this work. As an additional quality assurance check, CMMI also has these data reviewed by a qualified radiation health physicist (for this Program Project, Dr. Jeff Siegel). This core also is responsible for processing pharmacokinetic data.

剂量测定核心已在CMMI建立了大约6年。这个核心的目的是 开发用于处理CMMI赞助的药代动力学和剂量测定数据的标准程序 临床试验，但该核心也为CMMI的研究人员提供了临床前评估。核心是 负责CMMI需要其成像协议和 确保内部和在壁外站点的所有设备都得到适当校准和维护。这 核心收到由研究地点进行CMMI进行的所有成像研究的数字和硬拷贝 临床方案。然后，核心将审查这些图像并准备感兴趣的区域 可以生成时间活性曲线。训练有素的核医师和核医学技术人员 监督这项工作。作为额外的质量保证检查，CMMI还将这些数据审查了 合格的辐射健康物理学家（该计划项目Jeff Siegel博士）。这个核心也是 负责处理药代动力学数据。