A 3-D Interactive Atlas of the Hand & Wrist Joints

手部 3D 互动图集

• 批准号: 7477365
• 负责人: WILLIAM Paul BROWN
• 金额: $ 29.75万
• 依托单位: BROWN AND HERBRANSON IMAGING
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477365
• 关键词: 3-Dimensional; Age; Anatomy; Animals; Area; Arthritis; Atlases; Biochemical; Biomechanics; Bone Density; Bone Tissue; Bone and Cartilage Funding; Cadaver; Carpometacarpal joint structure; Characteristics; Clinical; Clinical Medicine; Collaborations; Collection; Color; Condition; Data; Data Set; Databases; Development; Device or Instrument Development; Devices; Discipline; Disease; Distal; Education; Educational Models; Educational process of instructing; Embalming; Engineering; Environment; Epidemic; Ethnic Origin; Evaluation; Evolution; Foundations; Future; Gender; Grant; Hand; Hand functions; Health; High Resolution Computed Tomography; Hominidae; Human; Image; Imagery; Industry; Injury; Joints; Knowledge; Lead; Length; Libraries; Licensing; Ligaments; Magnetic Resonance Imaging; Maps; Medical; Medical Education; Medicine; Methodology; Microscopic; Mission; Modality; Modeling; Morbidity - disease rate; Motion; Muscle; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Museums; Natural History; Nerve; Osteoporosis; Pathologic; Patient Care; Pattern; Periosteum; Phase; Photography; Physicians; Physiological; Preservation Technique; Prostheses and Implants; Protocols documentation; Reporting; Research; Resolution; Rivers; Safety; Scanning; Science; Scientist; Slice; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Specimen; Structure; Students; Surgeon; Synchrotrons; Technology; Telephone; Tendon structure; Testing; Thumb structure; Tissue Model; Tissues; Tooth structure; Trabecular Pattern; Trauma; United States; Upper Extremity; Visual; Work; Wrist; Wrist joint; X-Ray Computed Tomography; aging population; arthropathies; base; bench to bedside; bone; clinically relevant; comparative; concept; cranium; day; digital; implantable device; improved; indexing; innovation; insight; interest; novel; osteoporosis with pathological fracture; radius bone structure; research and development; size; soft tissue; stereoscopic; substantia spongiosa; synchrotron radiation; tool; translational medicine; trapezium; tumor; virtual

DESCRIPTION (provided by applicant): This project will produce innovative models of small joints with high-resolution imaging modalities, creating an anatomical library that will serve as a foundation for developing morphologically and biomechanical accurate models of the musculoskeletal system. This will build substantially on the voxel modeling of the Visual Human Project, providing precise volumetric information on human variability at microscopic levels. Joints of the hand and wrist will be imaged using high-resolution computed tomography (CT) and synchrotron radiation at sizes between 30-130 microns, and the same specimens will be imaged using high-resolution magnetic resonance imaging (MRI). These images will be combined with photographic images of the specimens sliced at 30 microns, permitting a comprehensive multi-modal dataset. Viewing protocols developed will permit segmentation of discrete anatomical structures, as well as define the important interrelationship of supporting soft tissues (tendon, ligament, and periosteum) around joints. Such visualization will also permit identification of the ultrastructural anatomy; for instance, how the insertion of tendon and ligament corresponds to adjacent bone patterns which reflect regions of physiologic loading or abnormal wear patterns. This provides a high-resolution map of function in the normal and diseased state, such as in arthritis. Application of these sophisticated viewing protocols will create an Atlas-At-Large, and will be used to develop interactive hand and wrist teaching models of annotated, rotating volumetric bones and joints, which correlate to modules about hand function and clinical conditions. Furthermore, these datasets will provide comprehensive information from several cadaver and bone specimens, providing insight into human variability that will improve implant and device development for trauma and arthritis applications. The mission of the Bone and Joint Decade is to further education, recognition and treatment of musculoskeletal health, which is a monumental task when joint disease and injuries related to osteoporosis have reached epidemic proportions in the United States. The digital anatomical libraries of small joints produced from this project will help in that mission, to further the understanding and treatment of the musculoskeletal system.

描述（由申请人提供）：该项目将产生具有高分辨率成像方式的小关节的创新模型，创建一个解剖学库，该图书馆将成为开发肌肉骨骼系统的形态和生物力学准确模型的基础。这将基于视觉人类项目的体素建模，从而提供有关显微镜水平人类可变性的精确体积信息。将使用高分辨率计算机断层扫描（CT）和尺寸的同步加速器辐射在30-130微米之间进行成像，并使用高分辨率的磁共振成像（MRI）成像相同的标本。这些图像将与切成30微米的样品的摄影图像结合使用，从而允许全面的多模式数据集。开发的查看方案将允许分割离散解剖结构，并定义关节周围支撑软组织（肌腱，韧带和骨膜）的重要相互关系。这种可视化还将允许识别超微结构解剖结构。例如，肌腱和韧带的插入方式对应于相邻的骨骼模式，这些骨骼模式反映了生理负荷或异常磨损模式的区域。这为正常状态和患病状态（例如关节炎）提供了高分辨率的功能图。这些复杂的观看协议的应用将创建一个大试验，并将用于开发带注释的，旋转的体积骨骼和关节的交互式手和腕部教学模型，这与有关手功能和临床条件的模块相关。此外，这些数据集将提供来自几个尸体和骨标本的全面信息，从而洞悉人类可变性，这将改善植入物和设备开发创伤和关节炎的应用。骨骼和联合十年的任务是进一步的教育，认可和治疗肌肉骨骼健康，这是美国的一项重要任务，与骨质疏松相关的联合疾病和伤害达到了美国的流行比例。该项目产生的小关节的数字解剖库将有助于该任务，以进一步了解和治疗肌肉骨骼系统。