ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY

生物医学研究群体的建立/维护

• 批准号: 6793631
• 负责人: WILLIAM C SATTERFIELD
• 金额: $ 374.16万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6793631
• 关键词: Pan; animal breeding; animal care; animal colony; biomedical resource; cooperative study; ethology

(Adapted from the applicant's abstract): This cooperative agreement combines the strengths of two previously funded, highly successful programs for chimpanzee care breeding, and research; The UT M.D. Anderson Cancer Center (UT-MDACC), Department of Veterinary Sciences in Bastrop (DVSB) and the PFA in Mesa. Through a subcontract with PFA and the addition of new housing facilities at DVSB, the investigators can significantly increase the number of chimpanzees under an experienced, coordinated veterinary care, management, and research program. They have a detailed Memorandum of Understanding with PFA to perform for them as a subcontractor. By incorporating PFA into the research-oriented mission of DVSB, they can significantly increase the likelihood of satisfying the proposed need for a stable long-term national resource of chimpanzees for biomedical research. This application will dedicate 186 of the most demographically balanced, physically and behaviorally healthy chimpanzees in the country to the management of an internationally recognized research institution. This dedicated colony will serve as a Core resource to support peer-reviewed investigations requiring the chimpanzee model. When appropriate, the investigators will be charged for using these chimpanzees. In addition to having biohazard and conventional holding facilities for all age chimpanzees, the DVSB can provide an array of molecular, viral, immunological, anatomical and clinical pathology research services. Increasing investigator awareness of the availability of chimpanzees, appropriate investigative housing and sophisticated research support capabilities of DVSB should enhance the prudent investigative use of the chimpanzee. The investigators proposed new biomedical research and housing facilities that will support an additional 100-175 chimpanzees. The proposed design maximizes flexibility and options for housing individuals and small or large groups. The current and new facilities will provide a balance between an enriched and a protected habitat. To complement the facilities, they have sufficient numbers of dedicated and experienced professional and technical personnel. All of their objectives can be accomplished in a manner meeting societal expectations for the humane care and use of chimpanzees. They will continue to perform clinical investigations to improve chimpanzee health, genetics, management and well-being. Positive reinforcement training techniques will be refined to increase voluntary cooperation of chimpanzees with numerous research and investigative procedures. The proposed plan and facilities have a 20-year track record to substantiate their success in cost- effective delivery of high quality husbandry, care, and research with the chimpanzee.

（改编自申请人的摘要）：该合作协议 结合了两个先前资助的非常成功的计划的优势 用于黑猩猩护理育种和研究； UT M.D. Anderson癌症中心 （UT-MDACC），Bastrop（DVSB）的兽医科学系和PFA 台面。 通过与PFA的分包合同并增加新住房 DVSB的设施，调查人员可以显着增加 黑猩猩在经验丰富的，协调的兽医护理，管理和 研究计划。 他们有详细的与PFA理解的备忘录 为他们作为分包商表演。 通过将PFA纳入 以研究为导向的DVSB使命，它们可以大大增加 满足拟议的长期国家需求的可能性 黑猩猩用于生物医学研究的资源。 该应用程序将专用186个人口平衡的186个 该国的身体和行为健康的黑猩猩 国际认可的研究机构的管理。 这 专用殖民地将作为支持同行评审的核心资源 需要黑猩猩模型的调查。 适当的时候， 调查人员使用这些黑猩猩将被收取。 此外 为所有年龄的黑猩猩都有生物危害和常规持有设施， DVSB可以提供一系列分子，病毒，免疫学，解剖学 和临床病理研究服务。 提高调查员的意识 黑猩猩的可用性，适当的调查住房和 DVSB的复杂研究支持功能应增强审慎 黑猩猩的调查用途。 调查人员提出了新的生物医学研究和住房设施 将支持另外的100-175黑猩猩。 提出的设计最大化 住房个人和小组的灵活性和选择。 当前和新设施将在富集和 受保护的栖息地。 为了补充设施，他们有足够的 专业和经验丰富的专业和技术人员的数量。 他们所有的目标都可以以满足社会的方式实现 对人道关怀和黑猩猩的使用的期望。 他们将继续进行临床调查以改善黑猩猩 健康，遗传学，管理和福祉。 积极的强化训练 技术将被改进，以增加黑猩猩的自愿合作 通过许多研究和调查程序。 拟议的计划和 设施有20年的记录，以证实他们在成本上的成功 - 有效地提供高质量的畜牧业，护理和研究 黑猩猩。