BCD Research Infrastructure Enhancement Program

BCD 研究基础设施增强计划

• 批准号: 6951074
• 负责人: DAVID S. CARLSON
• 金额: $ 142.13万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951074
• 关键词: continuing education; cooperative study; craniofacial; dental personnel; dentistry; dentistry education; disease /disorder prevention /control; education evaluation /planning; growth /development; health science research support; postgraduate education; role model; teacher

DESCRIPTION (provided by applicant): The objective of the Infrastructure Improvement Grant is to strengthen the research infrastructure of Baylor College of Dentistry (BCD) by recruiting and developing outstanding faculty in tenure track positions and by developing the core infrastructure necessary to make this faculty successful with respect to basic, translational, and clinical research grants. These objectives will be accomplished through collaboration with the Institute of Biosciences and Technology (IBT) and leveraging of the federal funds through significant matching funds. A Critical Needs Assessment found that BCD has strengths with respect to basic science faculty, advanced clinical and Ph.D. programs, and research facilities, including a new Research Sciences Building that will come on-line in 2004 and 2005. However, BCD lacks a critical mass of successful research faculty and mentors in the basic sciences, especially in the areas of translational and clinical research, with sustained extramural grant funding. Based on a review of areas of strengths, it was decided that BCD should emphasize the research theme of developmental biology and genetics of the craniofacial complex, with special emphasis on the causes, prevention, and treatment of craniofacial deformities that might be expressed early in development and during the postnatal growth period. The Institutional Enhancement Plan is based primarily on formal collaboration with the IBT, and includes: (1) recruitment of Dr. Richard Finnell as a Magnet Investigator and four additional outstanding senior IBT scientists as research mentors; (2) recruitment of a new chair of the Department of Biomedical Sciences at BCD as a second Magnet Investigator; (3) recruitment of three junior faculty to BCD; and (4) comprehensive faculty exchanges. The Implementation Plan is already underway with recruitment of all IBT faculty and naming of the ESPAC. Detailed Letters of Institutional Commitment are provided from the President of the HSC, Dean of the Dental School, and the President of the Baylor Oral Health Foundation.

描述（由申请人提供）：基础设施改善补助金的目的是通过招募和培养终身教授职位的杰出教师以及开发使该教师取得成功所需的核心基础设施来加强贝勒牙科学院 (BCD) 的研究基础设施关于基础、转化和临床研究资助。这些目标将通过与生物科学与技术研究所（IBT）的合作以及通过大量配套资金利用联邦资金来实现。关键需求评估发现，BCD 在基础科学教师、高级临床和博士方面具有优势。计划和研究设施，包括将于 2004 年和 2005 年投入使用的新研究科学研究大楼。然而，BCD 在基础科学方面缺乏大量成功的研究人员和导师，特别是在转化和临床研究领域，并有持续的外部拨款资助。基于对优势领域的回顾，决定BCD应强调颅面复合体的发育生物学和遗传学的研究主题，特别强调发育早期可能表现的颅面畸形的原因、预防和治疗以及产后生长期。机构增强计划主要基于与IBT的正式合作，包括：（1）聘请Richard Finnell博士作为磁力研究员，并另外聘用四位杰出的IBT资深科学家作为研究导师； (2) 招聘 BCD 生物医学科学系新任系主任作为第二位 Magnet 研究员； (3) BCD招聘3名初级教师； （四）全面的师资交流。实施计划已经开始实施，包括招聘所有 IBT 教员和命名 ESPAC。 HSC 主席、牙科学院院长和贝勒口腔健康基金会主席提供了详细的机构承诺函。

项目成果

Cleft lip and palate genetics and application in early embryological development.

唇腭裂遗传学及其在早期胚胎发育中的应用。

• 发表时间: 2009-10
• 作者: Yu, Wenli;Serrano, Maria;Miguel, Symone San;Ruest, L Bruno;Svoboda, Kathy K H
• 通讯作者: Svoboda, Kathy K H

Analysis of neural crest cell fate during cardiovascular development using Cre-activated lacZ/β-galactosidase staining.

使用 Cre 激活 lacZ/β-半乳糖苷酶染色分析心血管发育过程中的神经嵴细胞命运。

• 发表时间: 2012
• 作者: Zhang, Yanping;Ruest, L Bruno
• 通讯作者: Ruest, L Bruno

Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.

下颌弓神经嵴细胞中 Twist1 的特异性失活会影响下颌支的发育，并揭示与 hand2 的相互作用。

• 发表时间: 2012-05
• 作者: Zhang, Yanping;Blackwell, Evan L;McKnight, Mitchell T;Knutsen, Gregory R;Vu, Wendy T;Ruest, L Bruno
• 通讯作者: Ruest, L Bruno

Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2.

黄体酮对内皮素-a 受体表达的控制通过与 Gata2 的协同作用得到增强。

• 发表时间: 2013-06
• 作者: Zhang, Yanping;Knutsen, Gregory R;Brown, Matthew D;Ruest, L Bruno
• 通讯作者: Ruest, L Bruno

Erratum : Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations (The American Journal of Human Genetics (2017) 101(5) (789–802) (S0002929717303877) (10.1016/j.ajhg.2017.09.018))

勘误：全外显子组关联研究确定先天性肾畸形中的 GREB1L 突变（美国人类遗传学杂志 (2017) 101(5) (789â802) (S0002929717303877) (10.1016/j.ajhg.2017.09.018))

• DOI: 10.1111/cge.12741
• 发表时间: 2017-12-07
• 期刊: American Journal of Human Genetics
• 影响因子: 9.8
• 作者: S. Sanna;Kamal Khan;R. Westl;Priya Krithivasan;Lorraine Fievet;H. Rasouly;I. Ionita;Valentina Capone;D. Fasel;K. Kiryluk;S. Kamalakaran;M. Bodria;E. Otto;M. Sampson;C. Gillies;V. Vega;K. Vukojević;Igor Pediaditakis;Gabriel S. Makar;A. Mitrotti;M. Verbitsky;Jeremiah Martino;Qingxue Liu;Y. Na;V. Goj;G. Ardissino;M. Gigante;L. Gesualdo;M. Janezcko;M. Zaniew;C. Mendelsohn;S. Shril;F. Hildebr;t;t;J. V. Wijk;Adela Arapović;M. Saraga;L. Allegri;C. Izzi;F. Scolari;V. Tasic;G. Ghiggeri;A. Latos;A. Materna;S. Mane;D. Goldstein;R. Lifton;N. Katsanis;E. Davis;A. Gharavi
• 通讯作者: A. Gharavi