Development of a quasi-CBCT system for image-guided radiotherapy

图像引导放射治疗准CBCT系统的开发

• 批准号: 7406384
• 负责人: Tiezhi Zhang
• 金额: $ 22.59万
• 依托单位: WILLIAM BEAUMONT HOSPITAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7406384
• 关键词: Algorithms; Clinical; Defect; Development; Diagnostic; Diagnostic Imaging; Image; Inferior; Measures; Medical; Modality; Noise; Normal tissue morphology; Numbers; Performance; Quality of life; Radiation therapy; Research; Resolution; Retinal Cone; Rotation; Scanning; Signal Transduction; Source; Spiral Computed Tomography; Structure; System; Techniques; Testing; Tube; base; cone-beam computed tomography; design; detector; image guided intervention; improved; innovation; killings; novel; prototype; reconstruction; tumor; two-dimensional

DESCRIPTION (provided by applicant): Cone-beam computed tomography (CBCT) is an important online imaging modality for image-guided radiotherapy (IGRT) as well as other forms of image guided interventions. However, current CBCT image quality is inferior to that of the diagnostic fan beam CT. The image quality problem is inherent in the design of the current CBCT system, which is composed of a point x-ray source and a two-dimensional flat panel imager (FPI). Excessive x-ray scatters, the use of low performance FPI, and reconstruction degradation at large cone angles are three major sources of the degradation of image quality. The inferior image quality of CBCT limits the use of this modality for important new IGRT treatment techniques. We have designed a novel quasi-CBCT scanning system comprising a linear scan x-ray source and a linear discrete x-ray detector array. This imaging system will overcome the defects inherent in FPI-based CBCT and thereby produce online images with diagnostic quality. The linear x-ray tube and detector array are aligned perpendicular to and within the rotation plane, respectively. The x-ray beams are narrowly collimated into fan beams and scan in the z-direction electronically. This system will produce diagnostic quality online images for IGRT due to its scatter rejection mechanism and high-performance discrete x-ray detectors. Besides improved image quality, this system also has larger clearance due to its slim structure. Diagnostic online images will facilitate new IGRT techniques with better tumor killing and normal tissue sparing. This innovative design will also have huge impact on other forms of image guided intervention as well as diagnostic imaging. A quasi-CBCT bench-top system will be built in this research. The feasibility and improvement of image quality of the quasi-CBCT system will be studied. Techniques and parameters for clinical implementation will be obtained. NARRATIVE In this project, we will develop a novel quasi cone beam computed tomography (CBCT) system for image guided radiotherapy (IGRT) as well as other forms of image guided interventions. This system will solve the inherent problem of current flat-panel based CBCT and will produce online images with diagnostic quality. Clinical implementation of this innovative online imaging system will facilitate new IGRT techniques that are impossible with the inferior image quality of current CBCT. Once developed, this mobile and diagnostic CT imaging system will have huge impacts on many other forms of medical practice.

描述（由申请人提供）：锥束计算机断层扫描（CBCT）是图像引导放射疗法（IGRT）以及其他形式的图像引导干预措施的重要在线成像方式。但是，当前的CBCT图像质量不如诊断风扇束CT。图像质量问题是当前CBCT系统的设计固有的，该系统由点X射线源和二维平板成像仪（FPI）组成。过度的X射线散射，低性能FPI的使用以及在大锥角处的重建降解是图像质量降解的三个主要来源。 CBCT的下图质量限制了这种方式用于重要的新IGRT治疗技术。我们设计了一种新型的准CBCT扫描系统，该系统包括线性扫描X射线源和线性离散X射线检测器阵列。该成像系统将克服基于FPI的CBCT中固有的缺陷，从而产生具有诊断质量的在线图像。线性X射线管和检测器阵列分别垂直于旋转平面和内部对齐。将X射线梁狭窄地准直插入风扇梁中，并以电子方式扫描Z方向。由于其散布拒绝机制和高性能离散的X射线探测器，该系统将为IGRT生成诊断质量的在线图像。除了提高图像质量外，由于其细长的结构，该系统还具有更大的间隙。诊断在线图像将促进新的IGRT技术，并具有更好的肿瘤杀伤和正常组织的保留。这种创新的设计还将对其他形式的图像引导干预以及诊断成像产生巨大影响。这项研究将建立一个准CBCT台面系统。将研究准CBCT系统的图像质量的可行性和改进。将获得用于临床实施的技术和参数。 在这个项目中，我们将开发一种新型的准锥束计算机断层扫描（CBCT）系统，用于图像引导放射疗法（IGRT）以及其他形式的图像引导干预措施。该系统将解决当前基于平板的CBCT的固有问题，并将产生具有诊断质量的在线图像。这种创新的在线成像系统的临床实施将有助于新的IGRT技术，而当前CBCT的劣质图像质量是不可能的。一旦开发，这种移动和诊断CT成像系统将对许多其他形式的医学实践产生巨大影响。