Pressure-enhanced near-infrared breast cancer imaging

压力增强近红外乳腺癌成像

• 批准号: 7344778
• 负责人: SHUDONG JIANG
• 金额: $ 10.03万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-23 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7344778
• 关键词: Biochemistry; Biometry; Blood Vessels; Breast; Breast Cancer Detection; Clinical Trials; Condition; Country; Data; Diagnostic; Engineering; Environment; Event; Female breast; Fiber; Glass; Goals; Graduate Education; Group Meetings; Hemoglobin; Human; Image; Knowledge; Mammary Gland Parenchyma; Measurement; Measures; Medical; Medical center; Modality; Nature; Norris Cotton Cancer Center; Optical Tomography; Optics; Oxygen; Plastics; Procedures; Property; Protocols documentation; Research; Research Personnel; Research Project Grants; Resolution; Resources; System; Techniques; Testing; Tissue Engineering; Tissues; Tumor Tissue; Water; Work; breast cancer diagnosis; cancer imaging; career; college; experience; field study; improved; in vivo; lectures; malignant breast neoplasm; pressure; research clinical testing; response; symposium; tissue oxygenation; tomography; tool; tumor; Biochemistry; Biometry; Blood Vessels; Breast; Breast Cancer Detection; Clinical Trials; Condition; Country; Data; Diagnostic; Engineering; Environment; Event; Female breast; Fiber; Glass; Goals; Graduate Education; Group Meetings; Hemoglobin; Human; Image; Knowledge; Mammary Gland Parenchyma; Measurement; Measures; Medical; Medical center; Modality; Nature; Norris Cotton Cancer Center; Optical Tomography; Optics; Oxygen; Plastics; Procedures; Property; Protocols documentation; Research; Research Personnel; Research Project Grants; Resolution; Resources; System; Techniques; Testing; Tissue Engineering; Tissues; Tumor Tissue; Water; Work; breast cancer diagnosis; cancer imaging; career; college; experience; field study; improved; in vivo; lectures; malignant breast neoplasm; pressure; research clinical testing; response; symposium; tissue oxygenation; tomography; tool; tumor

DESCRIPTION (provided by applicant): The candidate has worked in the optoelectronics field before changing her field of study to breast cancer optical tomography. The long-term career goal of the candidate is to be an independent researcher who has a unique set of knowledge and breadth of experience in both the Optoelectronics and biomedical fields, and can work to develop new tools for diagnostic medical applications. The immediate goal of the candidate is to develop a Near-Infrared (NIR) tomography system to have capabilities of rapidly imaging both long-term and short-term changes within the breast of total hemoglobin (HbT), oxygen saturation (StO2), water concentration, scattering power (SP) and scattering amplitude (SA). Furthermore, to establish a procedure of dynamic pressure-enhanced near-infrared breast cancer imaging by such a system. Dartmouth College has significant resources in the field of medical and engineering graduate education. Norris Cotton Cancer Center at the Dartmouth-Hitchcock Medical Center has been ranked as one of the 50 best treatment and research centers in the country. In this excellent environment, the candidate's research career will be developed by (i) taking courses in medical engineering, tissue biochemistry and biostatistics, (ii) taking part in related events, lectures, (iii) attending group meetings at the Norris Cotton Cancer Center, (iv) presenting research results at the most pertinent academic medical conferences, and (v) attending clinical evaluation and planning meetings. The research project of the candidate is to develop a dynamic pressure-enhanced NIR breast cancer imaging system with an optimized human protocol. NIR multi-spectral imaging is a unique tool for characterization of tissue composition changes in the female breast by providing images of HbT, StO2, water concentration, SP and SA. Measurement of the differences between long term and short term responses of breast tissue under different applied pressures has the capability of enhancing the contrast and resolution of breast cancer detection. This will provide a unique system for optical-elastic imaging of tissue. The overall goal of this proposal is to establish a vivo optical-elastic enhanced breast cancer detection technique to improve the contrast and resolution of breast cancer characterization. We hypothesize that normal breast tissue will deform and have strong dynamic and plastic deformation responses, whereas tumor tissue will have a lower dynamic and plastic response in comparison. The research will be carried out by 1) improving the current NIR multi-spectral system to have capabilities of imaging both long-term and short-term changes within the breast of HbT, StO2 ,water concentration, SP and SA; 2) using the improved NIR system to understand vivo long-term and short-term pressure responses of HbT, StO2, water concentration, SP and SA with respect to the breast tissue composition; and 3) to establish procedures and obtain initial data as to the optimal conditions for maximal contrast and resolution in this dynamic approach to breast cancer imaging.

描述（由申请人提供）：候选人在将她的研究领域改为乳腺癌光学断层扫描之前已在光电领域工作。候选人的长期职业目标是成为一名独立的研究人员，他在光电学和生物医学领域都拥有独特的知识和广度，并可以为诊断医学应用开发新的工具。候选人的直接目标是开发近红外（NIR）层析成像系统，以便在总血红蛋白（HBT），氧饱和度（STO2），水浓度，散射功率（SP）和散射疗法（SA）的乳房内快速成像长期和短期变化的能力。此外，通过这种系统建立一种动态增强近红外乳腺癌成像的程序。达特茅斯学院在医学和工程研究生教育领域拥有大量资源。达特茅斯 - 希区柯克医学中心的诺里斯棉花癌中心被评为该国50个最佳治疗和研究中心之一。在这个良好的环境中，候选人的研究职业将通过（i）参加医学工程，组织生物化学和生物统计学课程，（ii）参加相关活动，讲座，（iii）参加诺里斯棉花癌中心的小组会议，（IV），（iv）在最受欢迎的学术医学会议上和（V）颁发了（v）的研究结果，并在努力评估中进行了评估。候选人的研究项目是开发具有优化人类方案的动态增强NIR乳腺癌成像系统。 NIR多光谱成像是通过提供HBT，STO2，水浓度，SP和SA的图像来表征女性乳房中组织组成变化的独特工具。在不同的应用压力下，乳腺组织的长期和短期反应之间的差异的测量能够增强乳腺癌检测的对比度和分辨率。这将为组织的光弹性成像提供独特的系统。该提案的总体目标是建立一种体内光弹性增强的乳腺癌检测技术，以改善乳腺癌表征的对比度和分辨率。我们假设正常的乳腺组织会变形，并且具有强大的动态和塑性变形反应，而肿瘤组织的动态和塑性反应较低。这项研究将通过1）提高当前的NIR多光谱系统具有对HBT，STO2，水浓度，SP和SA的长期和短期变化进行成像的能力； 2）使用改进的NIR系统了解HBT，STO2，水浓度，SP和SA的长期和短期压力反应相对于乳腺组织组成； 3）建立程序并获得有关这种动态乳腺癌成像方法中最大对比度和分辨率的最佳条件的初始数据。