Mechanisms of Skeletal Muscle Fatigue in Aging Adults

老年人骨骼肌疲劳的机制

• 批准号: 7434513
• 负责人: JANE A KENT
• 金额: $ 13.21万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-15 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434513
• 关键词: Accounting; Activities of Daily Living; Adenosine Triphosphate; Adult; Affect; Age; Aging; Aging-Related Process; Anterior; Area; Arts; Blood flow; Collaborations; Complement; Condition; Contracts; Coupling; Creatine Kinase; Depth; Development; Doctor of Philosophy; Educational process of instructing; Elderly; Electric Stimulation; Electromyography; Energy Metabolism; Energy-Generating Resources; Ensure; Equilibrium; Exercise; Exhibits; Failure; Fatigue; Fatty acid glycerol esters; Fiber; Fostering; Foundations; Functional Imaging; Functional Magnetic Resonance Imaging; Gender; Goals; Human; Image; Impairment; Independent Living; Intervention; Intramuscular; Invasive; Investigation; Isometric Contraction; Isometric Exercise; K-Series Research Career Programs; Kinetics; Knee; Knowledge; Leg; Literature; Locomotion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maintenance; Measures; Membrane; Metabolic; Metabolic Pathway; Metabolism; Methodology; Motor; Muscle; Muscle Contraction; Muscle Fatigue; Muscle function; Numbers; Outcome; Oxidative Phosphorylation; Oxygen; Pathology; Pathway interactions; Performance; Perfusion; Peripheral; Phosphorus; Physical Function; Physical activity; Play; Plethysmography; Principal Investigator; Production; Productivity; Protocols documentation; Rate; Reaction; Relative (related person); Reliance; Reporting; Research; Research Personnel; Research Project Grants; Resistance; Risk; Role; Series; Skeletal Muscle; Skeletal system; Source; Specificity; Students; Techniques; Time; Training; Universities; Woman; Work; age difference; age effect; age related; aging population; anaerobic glycolysis; ankle joint dorsiflexor; base; career; design; falls; in vivo; loss of function; muscle metabolism; muscle strength; older men; pressure; programs; reactive hyperemia; research study; response; sedentary; sex; size; success; volunteer; young adult

DESCRIPTION (provided by applicant): The impact of old age on the magnitude and mechanisms of human skeletal muscle fatigue is not well understood. The candidate's long-term goal is to continue to contribute important new information about the effects of old age on muscle function, with particular reference to how sex and habitual physical activity may alter age-related changes in fatigue. This application is designed to complement the Pl's new R01 "Skeletal Muscle Fatigue in Older Adults." This career development award will allow the candidate to focus more fully on developing the depth and breadth of her research program, by providing release time from teaching responsibilities. Career development activities will comprise three main components: 1) enhancement of state-of-the-art magnetic resonance spectroscopy and imaging expertise, 2) development of expertise and new noninvasive methodologies for measuring skeletal muscle perfusion, and 3) strengthening of statistical design, analysis and interpretation knowledge relevant to this line of research. Collaborations with leading investigators on-campus (John Buonaccorsi, PhD) and at Yale University (Douglas Rothman, PhD) and JB Pierce Foundation (Steven Segal, PhD) will be fostered and strengthened during this period. The candidate will develop a new seminar series related to the training of graduate students and postdocs in the Responsible Conduct of Research. These activities will ensure the candidate's continued high level of productivity and enable the development of additional integrative research projects in this area. The Specific Aims of the Research Project are: 1) Metabolic Capacity: to determine whether older skeletal muscle exhibits a decreased capacity to produce ATP for energy in vivo; 2) Muscle Perfusion: to examine the relationships between ankle dorsiflexor muscle strength, contraction intensity and occlusion of blood flow; 3) Muscle Group Specificity in Fatigue: to determine the impact of muscle (knee extensors vs. dorsiflexors) and contraction type (intermittent vs. sustained) on the extent and mechanisms of fatigue in young and older adults; 4) Task Specificity in Fatigue: to investigate how task (isometric vs. dynamic contractions) affects the extent and mechanisms of fatigue in young and older men and women. Nonivasive measures of muscle activation, perfusion, metabolism and contractile function will be made using magnetic resonance spectroscopy and functional imaging, electromyography and electrical stimulation.

描述（由申请人提供）：老年对人骨骼肌疲劳的大小和机制的影响尚不清楚。候选人的长期目标是继续提供有关老年对肌肉功能影响的重要新信息，特别是指性别和习惯性体育锻炼如何改变与年龄相关的疲劳变化。该应用旨在补充PL的新R01“老年人的骨骼肌疲劳”。该职业发展奖将使候选人通过提供教学责任的发布时间来更加全面地放在开发研究计划的深度和广度上。职业发展活动将构成三个主要组成部分：1）提高最先进的磁共振光谱和成像专业知识，2）开发专业知识和新的无创方法，用于衡量骨骼肌灌注，3）增强与这一研究的统计设计，分析和解释知识相关的统计设计和解释知识。在此期间，与校园（John Buonaccorsi博士）以及耶鲁大学（道格拉斯·罗斯曼（Douglas Rothman））和JB Pierce基金会（Steven Segal，PhD）的合作将在此期间得到培养和加强。候选人将开发一个新的研讨会系列，该系列与研究生和博士后的培训有关。这些活动将确保候选人的持续高水平的生产率，并能够在该领域开发其他综合研究项目。 研究项目的具体目的是：1）代谢能力：确定较旧的骨骼肌是否表现出生产体内能量ATP的能力降低； 2）肌肉灌注：检查踝背屈力量，收缩强度和血流阻塞之间的关系； 3）疲劳中的肌肉群特异性：确定肌肉（膝盖伸肌与背屈者）和收缩类型（间歇性与维持）的影响，对年轻人和老年人的疲劳程度和机制； 4）疲劳的任务特异性：研究任务（等距和动态收缩）如何影响年轻男性和年龄较大的男女疲劳的程度和机制。使用磁共振光谱和功能成像，肌电图和电刺激进行肌肉激活，灌注，代谢和收缩功能的非分散测量。

项目成果

A computational model of torque generation: neural, contractile, metabolic and musculoskeletal components.

• DOI: 10.1371/journal.pone.0056013
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Callahan DM;Umberger BR;Kent-Braun JA
• 通讯作者: Kent-Braun JA

High-intensity interval training alters ATP pathway flux during maximal muscle contractions in humans.

高强度间歇训练会改变人类最大肌肉收缩期间的 ATP 通路通量。

• DOI: 10.1111/apha.12275
• 发表时间: 2014
• 期刊: Acta physiologica (Oxford, England)
• 作者: Larsen,RG;Maynard,L;Kent,JA
• 通讯作者: Kent,JA

Muscle weakness, fatigue, and torque variability: effects of age and mobility status.

• DOI: 10.1002/mus.23903
• 发表时间: 2014-02
• 期刊: MUSCLE & NERVE
• 影响因子: 3.4
• 作者: Kent-Braun, Jane A.;Callahan, Damien M.;Fay, Jessica L.;Foulis, Stephen A.;Buonaccorsi, John P.
• 通讯作者: Buonaccorsi, John P.

Intracellular energetics and critical PO2 in resting ischemic human skeletal muscle in vivo.

体内静息缺血人体骨骼肌的细胞内能量学和临界 PO2。

• DOI: 10.1152/ajpregu.00225.2010
• 发表时间: 2010
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Lanza,IanR;Tevald,MichaelA;Befroy,DouglasE;Kent-Braun,JaneA
• 通讯作者: Kent-Braun,JaneA