Preclinical Motor Function in Aging and Parkinsonism

衰老和帕金森病的临床前运动功能

• 批准号: 7447408
• 负责人: John A Stanford
• 金额: $ 11.45万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7447408
• 关键词: Accountability; Affect; Age; Age-Months; Aging; Animal Model; Animals; Award; Behavioral; Clinical Research; Condition; Corpus striatum structure; Counseling; Data; Dextroamphetamine; Discrimination; Dose; Electrodes; Electromyography; Electrophysiology (science); Event; Exhibits; Faculty; Flexor; Forelimb; Funding; Future; Gait; Hindlimb; Human; Independent Scientist Award; Ipsilateral; Isometric Exercise; Kansas; Laboratories; Learning; Lesion; Maps; Measurement; Measures; Medical center; Mentors; Methods; Modeling; Molecular; Motor; Motor Activity; Motor Cortex; Movement; Muscle; Neurophysiology - biologic function; Output; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Performance; Physical therapy; Physiology; Plastics; Pre-Clinical Model; Principal Investigator; Procedures; Psychological reinforcement; Public Health; Purpose; Rattus; Research; Resources; Source; Specific qualifier value; Techniques; Testing; Time; Training; Universities; Upper Extremity; Vision; Wages; Water; Week; Work; age group; age related; aged; behavior test; career; clinically relevant; desire; implantation; middle age; motor control; normal aging; novel; pre-clinical; preclinical study; programs; relating to nervous system; response; subcutaneous; translational study

DESCRIPTION (provided by applicant): The long-term vision of the principal investigator's (Pl)'s research program involves participating in translational studies of motor control in normal aging and Parkinson's disease (PD). The first step will be to develop clinically-relevant behavioral tests to assess motor control and related neural function in preclinical animal models. While the PI is currently funded to study age-related changes in rats' orolingual motor function, extension of the research program into more sophisticated behavioral and electrophysiological recording techniques is desired. Specifically, the PI needs additional time to work with Dr. Paul D. Cheney, who has agreed to train the PI to perform combined electrophysiological/electromyography (EMG) studies. This will allow the PI to study movement-related neural activity in greater detail and with greater precision. In addition, the PI plans to develop a forelimb force control task into a method to study functional cortical organization and reorganization as a function of age and 6-hydroxydopamine (6-OHDA) depletion in rats. Dr. Randy J. Nudo has agreed to train the PI in sensorimotor cortical mapping techniques so that this procedure can be incorporated into the Pi's laboratory. During the time of the award period, the PI will participate in a graduate-level course in the responsible conduct of scientific research. Dr. James Voogt, former chair of Molecular & Integrative Physiology at the University of Kansas Medical Center, has agreed to serve as a senior faculty mentor to the PI during the award period. Dr. Voogt will counsel the PI on career-related issues and serve as a source of accountability. The K02 award will allow the PI to spend 90% of his time conducting research. It will also provide valuable financial resources since it will allow for 90% of the Pi's salary to be returned to the PI for research-related purposes. Relevance to Public Health: This research should yield information regarding relationships between neural function and motor function in normal aging and in Parkinson's disease.

描述（由申请人提供）：主要研究者（PL）研究计划的长期视野涉及参与正常衰老和帕金森氏病（PD）运动控制的转化研究。第一步是开发与临床上相关的行为测试，以评估临床前动物模型中的运动控制和相关神经功能。虽然当前PI资助用于研究大鼠口语运动功能的年龄相关变化，但需要将研究计划扩展到更复杂的行为和电生理记录技术。具体而言，PI需要额外的时间与Paul D. Cheney博士一起工作，Paul D. Cheney博士已同意训练PI进行组合电生理/肌电图（EMG）研究。这将使PI能够更详细地研究与运动相关的神经活动。此外，PI计划将前肢控制任务开发为一种研究功能性皮质组织和重组的方法，这是大鼠年龄的函数和6-羟基多巴胺（6-OHDA）的耗竭。兰迪·J·努多（Randy J.在颁奖期间，PI将参加负责任的科学研究的研究生级课程。堪萨斯大学医学中心分子与综合生理学的前主席James Voogt博士已同意在奖项期间担任PI的高级教师导师。 VOOGT博士将向PI咨询与职业有关的问题，并作为问责制的来源。 K02奖将使PI花费90％的时间进行研究。它还将提供宝贵的财政资源，因为它将允许PI的90％的工资返还给PI，以进行研究相关。 与公共卫生有关： 这项研究应产生有关正常衰老和帕金森氏病中神经功能与运动功能之间关系的信息。