Clinical and Economic Evaluation of Breast MRI for High-Risk Screening
用于高风险筛查的乳腺 MRI 的临床和经济评估
基本信息
- 批准号:7471042
- 负责人:
- 金额:$ 14.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-06-01 至 2013-05-31
- 项目状态:已结题
- 来源:
- 关键词:AgeBRCA1 geneBRCA2 geneBiopsyBreastBreast Cancer DetectionBreast Cancer Early DetectionBreast Cancer ModelClinicalClinical InvestigatorClinical TrialsClinical effectivenessComplexComputer SimulationCosts and BenefitsDataDatabasesDetectionDisease modelEconomicsEffectivenessEvaluationEventFamily history ofGene MutationGeneral PopulationGenesGenetic Predisposition to DiseaseGenetic RiskGoalsGuidelinesHealth Services ResearchHereditary Breast CarcinomaHigh Risk WomanImageIntravenousInvasiveMagnetic Resonance ImagingMalignant NeoplasmsMammographyMethodologyMethodsModelingMutationNatural HistoryNumbersOutcomePathologicPatient PreferencesPositive Test ResultQuality of lifeRateRecommendationResearchRiskRoleScreening procedureStagingStandards of Weights and MeasuresSurrogate EndpointSurveysSusceptibility GeneTest ResultTimeTreatment ProtocolsWomanbasecancer riskcareercostcost effectivenesseconomic outcomeexperiencehealth economicsimprovedlifetime riskmalignant breast neoplasmmutation carriersizetumor
项目摘要
DESCRIPTION (provided by applicant): Project Summary: My career goal is to become an independent clinical investigator dedicated to optimizing the application of imaging in the early detection of breast cancer, with the ultimate aim of increasing the effectiveness of breast cancer screening. My experiences to date in clinical breast imaging, decision analytic methodologies, and health services research are uniquely suited to carry out the proposed research. The goal of the proposed research is to evaluate the clinical and economic consequences of MRI screening for breast cancer in women with increased genetic risk of breast cancer (>20% lifetime risk, including BRCA gene mutation carriers). The proposed research will: 1) develop and refine a complex computer simulation model, which will integrate currently available data and surrogate endpoints, 2) apply the model to predict long-term health and economic outcomes of screening with mammography and MRI, alone or in combination, and 3) evaluate patient preferences regarding trade-offs involved in adding MRI to current screening regimens. The research described in this proposal will carry out the following three specific aims: 1) Refine a Markov Monte Carlo disease model of breast cancer natural history and outcomes. 2) Compare the clinical effectiveness and cost-effectiveness of screening strategies utilizing mammography and MRI. 3) Determine patient preferences regarding false-positive test results to improve model estimates of clinical effectiveness and cost-effectiveness. Relevance: The proposed research will use computer simulation modeling to estimate the benefits and costs of using breast MRI for screening women at increased genetic risk of breast cancer. The results of the proposed research will provide data essential for developing standardized guidelines for optimizing the role of MRI in breast cancer screening.
描述(由申请人提供):项目摘要:我的职业目标是成为一名独立的临床研究者,致力于优化成像在早期发现乳腺癌中的应用,最终目的是提高乳腺癌筛查的有效性。我在临床乳房成像,决策分析方法和卫生服务研究中的经验非常适合进行拟议的研究。拟议研究的目的是评估患有乳腺癌遗传风险增加的女性MRI筛查乳腺癌的临床和经济后果(包括BRCA基因突变携带者在内的终生风险> 20%)。拟议的研究将:1)开发和完善复杂的计算机模拟模型,该模型将整合到当前可用的数据和替代端点,2)应用该模型来预测使用乳房X线摄影和MRI,单独或组合使用乳房X线摄影和MRI,单独或组合进行筛查的长期健康和经济成果,以及3)评估有关将MRI添加MRI添加到当前筛查方案的患者偏好。该提案中描述的研究将执行以下三个特定目的:1)改进马尔可夫·蒙特卡洛病自然史和结局模型。 2)比较利用乳房X线摄影和MRI的筛查策略的临床有效性和成本效益。 3)确定患者对假阳性测试结果的偏好,以提高临床有效性和成本效益的模型估计。相关性:拟议的研究将使用计算机模拟建模来估算使用乳房MRI筛查女性乳腺癌遗传风险增加的益处和成本。拟议研究的结果将为开发标准化指南提供优化MRI在乳腺癌筛查中的作用所必需的数据。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Janie M Lee其他文献
Janie M Lee的其他文献
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{{ truncateString('Janie M Lee', 18)}}的其他基金
Risk-based Imaging Strategies to Improve Breast Cancer Surveillance Outcomes
基于风险的影像策略可改善乳腺癌监测结果
- 批准号:
9982827 - 财政年份:2020
- 资助金额:
$ 14.11万 - 项目类别:
Risk-based Imaging Strategies to Improve Breast Cancer Surveillance Outcomes
基于风险的影像策略可改善乳腺癌监测结果
- 批准号:
10268352 - 财政年份:2011
- 资助金额:
$ 14.11万 - 项目类别:
Clinical and Economic Evaluation of Breast MRI for High-Risk Screening
用于高风险筛查的乳腺 MRI 的临床和经济评估
- 批准号:
8072600 - 财政年份:2008
- 资助金额:
$ 14.11万 - 项目类别:
Clinical and Economic Evaluation of Breast MRI for High-Risk Screening
乳腺 MRI 高风险筛查的临床和经济评估
- 批准号:
8257983 - 财政年份:2008
- 资助金额:
$ 14.11万 - 项目类别:
Clinical and Economic Evaluation of Breast MRI for High-Risk Screening
乳腺 MRI 高风险筛查的临床和经济评估
- 批准号:
7840453 - 财政年份:2008
- 资助金额:
$ 14.11万 - 项目类别:
Clinical and Economic Evaluation of Breast MRI for High-Risk Screening
用于高风险筛查的乳腺 MRI 的临床和经济评估
- 批准号:
7627980 - 财政年份:2008
- 资助金额:
$ 14.11万 - 项目类别:
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