COBRE: U KS: CORE A: ADMINISTRATION

COBRE：英国：核心 A：行政

• 批准号: 7381950
• 负责人: ROBERT P HANZLIK
• 金额: $ 42.09万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381950
• 关键词: COBRE; KS; CORE; ADMINISTRATION; COBRE; KS; CORE; ADMINISTRATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the proposed COBRE program is to establish a multidisciplinary research center focused on the use of the best experimental strategies available to probe the structural and functional properties of targeted proteins. The Center will provide intensive mentoring and superb research environments to enhance the competitiveness of several junior faculty working at the interface of protein chemistry and biology at University of Kansas in Lawrence (KU-L), University of Kansas Medical Center in Kansas City (KUMC), Kansas State University in Manhattan (KSU), and Wichita State University in Wichita (WSU). Participating faculty are based in a variety of departments, but they all share a strong interest in understanding the relationship between the structure of a specific protein and its functional role in the biology of the cell. The expertise represented by both the junior faculty participants and the senior mentoring faculty spans a broad range from mass spectrometry and protein crystallography to microbial pathogenesis and regulation of cell differentiation. However, all participants are united by a strong desire to apply effective modern technologies and experimental strategies to the characterization of important proteins. Our specific aims are: Aim 1. To establish a Center of Biomedical Research Excellence in Protein Structure and Function that will synergize with other regional efforts in proteomics and protein chemistry and biology. Aim 2. To organize a core of well-established, NIH-funded faculty members across the four institutions who will serve as mentors for recently hired and to-be-hired faculty in the area of protein structure and function, and to support 5 ¿ 6 independent research programs of junior faculty addressing significant problems in protein structure and function from a biological as well as chemical perspective in an integrated, multidisciplinary way. Over the 5-year period the COBRE program will assist at least 15 new faculty in developing highly competitive research programs in protein structure and function. Aim 3. To enhance the overall infrastructure for state-of-the-art research in protein structure and function through establishment of scientific cores that provides expertise and instrumentation in support of research in protein structure and function.

该主题项目是利用NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。拟议的COBRE计划的总体目标是建立一个多学科研究中心，该研究中心侧重于使用最佳的实验策略来探测目标蛋白的结构和功能特性。该中心将提供密集的心理和精湛的研究环境，以增强在堪萨斯大学堪萨斯大学堪萨斯大学医学中心（KUMC）（KUMC）的堪萨斯大学堪萨斯大学（KUMC）堪萨斯州立大学（KUMC）的堪萨斯大学堪萨斯大学（KUMC）堪萨斯州立大学（KSU）的堪萨斯大学医学中心（KSU）（KSU）（KSU）和WICHITA CO）的竞争力的竞争力。参与的教师基于各个部门，但他们都对理解特定蛋白质结构与其在细胞生物学中的功能作用之间的关系具有强烈的兴趣。初级教师参与者和高级心理教师所代表的专业知识跨越了从质谱和蛋白质晶体学到微生物发病机理和细胞分化调节的广泛范围。但是，所有参与者都强烈希望将有效的现代技术和实验策略应用于重要蛋白质的表征。我们的具体目的是：目标1。建立蛋白质结构和功能卓越生物医学研究中心，该中心将与蛋白质组学和蛋白质化学和生物学方面的其他区域努力协同作用。目的2。在四个机构中组织成熟的，由NIH资助的教师组成的核心，这些机构将在蛋白质结构和功能领域担任最近雇用和被雇用的教师的导师，并支持6个独立的研究计划，以解决生物学方面的质量和化学方面的跨性别培训，并在化学方面解决了跨越化学方面的重要问题。在5年的时间里，毛cre计划将至少有15个新教师开发蛋白质结构和功能方面的竞争激烈的研究计划。目的3。通过建立科学核心来增强蛋白质结构和功能最新研究的总体基础设施，从而提供专业知识和仪器，以支持蛋白质结构和功能研究。