INBRE RESEARCH CORE

INBRE研究核心

• 批准号: 7381585
• 负责人: ROBERTA Fishman COLMAN
• 金额: $ 30.03万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381585
• 关键词: INBRE; RESEARCH; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2006 Grant No. 2P20RR016472-2006 Research Core Core Objective: Strengthen the biomedical research capability in the Delaware INBRE network, through pilot research grants, mentoring, and access to infrastructure. Overview Report of the INBRE Research Committee Dr. Roberta F. Colman, UD Chemistry and Biochemistry, Chair The INBRE Research Committee is charged with providing guidance and research expertise to help the program meet its biomedical research goals. The committee is broadly representative of the state-wide institutions involved in the Delaware INBRE. In addition to Roberta F. Colman as Chair, the current members are: Brian Little and Nicholas Petrelli - Christiana Care Health System Tommy Frederick and Gus Ofosu - Delaware State University Joan Barber and Ray Lynch - Delaware Technical & Community College Vicky Funanage - Nemours Biomedical Research Abraham Lenhoff, Lisa Plowfield, and Karl Steiner - University of Delaware Bette Coplan, Paul DeGategno, and Malcolm D¿Souza, and Jonathan Kidd - Wesley College The second year of INBRE research involved two broad categories of projects: 1.) The completion of two-year mentored research grants by currently funded faculty; and 2.) The selection of a new cohort of INBRE grantees, whose research will begin June 1, 2006, shortly after the start of INBRE Year 3. Currently funded Grantees Research Meetings ¿ Oct. 19-20, 2005 EAB Meeting and Poster Session INBRE-funded researchers had the opportunity to present their research and talk with members of the INBRE External Advisory Board (EAB), the first time that the Board had an opportunity to meet network investigators in person. Faculty also involved their graduate students and research associates in the presentation, and undergraduate researchers were invited in a separate, special session. These sessions were characterized by informal, stimulating discussions. March 27-28, 2006 EAB Meeting and Investigator Presentations The scheduled March 27-28 External Advisory Board meeting will feature two separate sessions for INBRE-funded researchers to present their work to the Board. On March 27, the new cohort of INBRE researchers will introduce their projects slated to begin on June 1, 2006. The next day, the currently funded group of investigators will present a summary of work undertaken, and will offer an analysis of their key products, accomplishments, and future directions. Accomplishments of currently funded researchers are detailed in the subproject reports in this document. The group of currently-funded researchers, all junior faculty in the early stages of their careers, were selected for INBRE participation in the spring of 2004. Their grants began in the fall of 2004, and will conclude in the spring of 2006. During this interval, among the five investigators at the more research-intensive University of Delaware, one investigator received an R01, two investigators participated as Co-PIs on COBRE, two investigators received NSF CAREER awards, and one member of the group is PI on three additional NSF grants. Three of the five appear to have good traction toward independence. Two of the five continue to submit proposals toward support for their research areas. During the same period, one INBRE-funded investigator at Delaware State University (DSU) was awarded an NSF RUI with a focus on virology research. Also at DSU, one INBRE-funded investigator accepted a position at another university, and funds for that project have been redirected to a new junior faculty member, with approval from the INBRE EAB and NCRR. A third INBRE-funded investigator had to stop his program in year two due to illness; funds will be reassigned by the INBRE PI. At Christiana Care one investigator has been very actively involved in collaborations with UD and DBI researchers. These collaborations have led to several presentations and one publication. A second investigator decided to leave the INBRE research program due to pregnancy and childbirth. A third investigator accepted a position at another medical center outside the State of Delaware. Some of the funds freed up by these departures have been re-directed to establish a new collaboration with Nemours Biomedical Research, where an active biomedical translational research program is in place. In Year 3, Nemours will be a new partner in the Delaware INBRE. INBRE funding at Wesley College, an undergraduate institution, allowed investigators to pursue summer research that involved undergraduate students, and which led to their participation in several national meetings, and student co-authorship on one publication. Although the direct funding of this first phase of research projects will conclude in June 2006, the Delaware INBRE will continue to support investigators through core center fee waivers. Investigators in the INBRE Network may arrange to use, at no charge, core instrumentation centers including Bioinformatics, Bioimaging, DNA Sequencing and Genotyping, Mass Spectroscopy, Microarray, NMR and Protein Production and Analysis. New Delaware INBRE research solicitation The Delaware INBRE research and administrative leadership recognized an important opportunity to place a sharper research focus for grants provided to researchers in the next three years of the program. The new focus, on basic and translational work in cancer, builds on strengths at the University of Delaware, and the interests of the Helen F. Graham Cancer Center at INBRE partner Christiana Care Health System and at Nemours Biomedical Research. The new focus did not eliminate consideration of other types of basic research, but instead offered some common ground upon which to build a more cohesive community among INBRE investigators. In addition, the decision was made to open the call for proposals to both junior and senior investigators. This approach will lead to a stronger group of faculty researchers who can build close collaborations and benefit from each other within the broader goal of establishing a growing biomedical research capability in Delaware. A new round of INBRE-funded grants was announced in October 2005, and the announcements were circulated to Deans and Chairs among Delaware INBRE partners for distribution broadly to faculty. The INBRE RFP, instructions and forms were posted on the DBI website, and DBI staff responded to questions as needed. The new round of INBRE grants was designed to be similar to an NIH R03 in intent, and provided $160k in direct costs over a period of 32 months. Proposals were submitted in December 2005. The INBRE research committee reviewed and scored the 31 proposals submitted. Reviewers used the following set of weighted criteria to score each proposal: ¿ Scientific/ biomedical merit 50% ¿ Contribution to the Delaware cancer initiative. 15% ¿ Undergraduate involvement 10% ¿ Interdisciplinary component. 10% ¿ Inter-institutional component 5% ¿ Use of core centers 5% ¿ Potential to lead to an NIH grant application 5% In January 2006, the committee¿s recommended 13 choices were sent to the EAB for review and approval. In February 2006, the EAB completed the approval process. Based on its experience in the INBRE program during Years 1 & 2, Christiana Care decided that it could best contribute to and benefit from the INBRE program objectives by using some of its funding to support a program at Nemours Biomedical Research and to support one of the junior faculty members at the University of Delaware whose research closely matches the cancer focus of the Helen F. Graham, Cancer Center. Dr. Nicholas Petrelli, Medical Director of the Cancer Center, will serve as the mentor for this project, conducted by Dr. Deni Galileo, and Assistant Professor at the University of Delaware¿s Department of Biological Sciences. This collaboration fits well into a larger plan to establish a Center for Translational Cancer Research (CTCR). The CTCR will be launched as a virtual entity between UD, DBI, Christiana Care and Nemours. Dr. Cindy Farach-Carson, one of the new faculty in INBRE Year 3, will serve as CTCR¿s Founding Director, and recurring funds for CTCR have been included in the Governor¿s budget request for 2007. New INBRE Researchers and Project Titles: University of Delaware: Six 32-month projects: Farach-Carson, M. Cynthia - Professor, Biological Sciences Electrospun Collagen Scaffolds for Development of 3-D Cellular Models for Testing Anti-Neoplastic Agents Galileo, Deni ¿ Assistant Professor, Biological Sciences Autocrine Stimulation of Primary and Metastatic Brain Cancer Cells *(Project funded under the Christiana Care budget allocation) Johnston, Murray ¿ Professor, Chemistry and Biochemistry Mason, Robert ¿ Director, Cell Science Core, Nemours Proteomic Analysis of Apoptotic Mechanisms in Cancer Kambhamettu, Chandra ¿ Associate Professor, Computer and Information Sciences 3-D Image Analysis Algorithms for Automatic Computation of Ground Glass Opacity of Lung Tumors Panchapakesan, Balaji - Assistant Professor, Electrical and Computer Engineering Nanotechnology for Cancer Detection and Therapeutics Sikes, Robert - Assistant Professor, Biological Sciences Role of IGFBP-2 Fragments in Development of Androgen Insensitive Prostate Cancer Delaware State University: Four 32-month projects (plus 1 continuing project): Besong, Samuel A. ¿ Associate Professor, Family and Consumer Sciences Hepatic Lipid Metabolism and Gene Expression in Hen DiMaria, Peter - Associate Professor, Chemistry RNA Cap Hypermethylases in Microsporidia Harrington, Melissa ¿ Associate Professor, Biology Davis, Leonard ¿ Associate Professor, Biology Pokrajac, Dragoljub ¿ Assistant Professor, Computer & Information Science Investigating the Neurobiology of Sensory Processing and Learning in an Invertebrate Model System Liu, Fengshan ¿ Professor, Applied Mathematics and Theoretical Physics Analysis of 3-D Breast Surface Deformation during Mammographic Compression Sabrina Brougher ¿ Assistant Professor, Biology *(Continuing Project) Characterization of Surfactant Protein Expression in Avian Lung as a Model for Upper Respiratory Disease in Humans Wesley College: Three one-year projects: D'Souza, Malcolm ¿ Professor, Chemistry Extent of Nucleophilic Participation in Acyl, Sulfonyl and Sulfamoyl Halides Everett, Lynn ¿ Associate Professor, Biology Genetic Diversity in Borrelia burgdorferi Kidd, Jonathan ¿ Professor, Biology Curran, Kathleen ¿ Associate Professor, Biology Distribution of Lyme Disease and Other Tick-borne Diseases in Del

该主题是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。特拉华州INBRE年度进度报告（4月）2006年赠款2P20RR016472-2006研究核心目标：通过试验研究赠款，心理和获得基础设施的访问，增强了特拉华近亲网络中的生物医学研究能力。 INBRE研究委员会的概述报告Roberta F. Colman博士，UD化学和生物化学主席Inbre研究委员会主席负责提供指导和研究专业知识，以帮助该计划实现其生物医学研究目标。该委员会广泛地代表了特拉华州涉及的全州机构。除罗伯塔·F·科尔曼（Roberta F. Colman）担任主席外，现任成员还包括：布莱恩·利特尔（Brian Little）和尼古拉斯·佩特雷（Nicholas Petrelli） - 克里斯蒂安娜（Nicholas Petrelli） - 克里斯蒂安娜（Christiana Care）保健系统汤米·弗雷德里克（Tommy Frederick）和古斯（Gus ofou） - 特拉华州立大学琼·巴伯（Joan Barber）和雷·莱恩奇（Ray Lynch） - 特拉华州技术与社区学院维卡·菲尼亚奇（Vicky Funanage） Coplan，Paul DeGategno和MalcolmD¿Souza和Jonathan Kidd-卫斯理学院的第二年Inbre Research涉及两个广泛的项目：1。）目前资助的教职员工完成了为期两年的指导研究赠款； and 2.) The selection of a new cohort of INBRE grantees, whose research will begin June 1, 2006, shortly after the start of INBRE Year 3. Currently funded Grantees Research Meetings ¿ Oct. 19-20, 2005 EAB Meeting and Poster Session INBRE-funded researchers had the opportunity to present their research and talk with members of the INBRE External Advisory Board (EAB), the first time that the Board had an opportunity to meet network investigators in person.教职员工还参与了他们的研究生和研究伙伴的演讲，并邀请了本科研究人员参加另一项特别会议。这些会话的特征是非正式的，令人兴奋的讨论。 2006年3月27日至28日，EAB会议和调查员演讲计划于3月27日至28日外部顾问委员会会议将为Inbre资助的研究人员提供两次单独的会议，以向董事会介绍其工作。 3月27日，新的INBRE研究人员将介绍其计划于2006年6月1日开始的项目。第二天，当前资助的研究人员将提出一份工作摘要，并将对其关键产品，成就，成就和未来方向进行分析。本文档的subproject报告中详细介绍了当前资助的研究人员的成就。当前资助的研究人员是职业生涯初期的所有初级教师，都被选为2004年春季的INBRE参与。他们的赠款始于2004年秋季，并将包括2006年春季。在此间隔中，在此间隔中，在五名调查人员中，一名调查人员接受了一名研究人员，两位调查人员是R01的研究人员，两名调查人员，两位调查人员，CORER的参与者，CO-PIS的参与者是R01的参与者，奖项，该小组的一名成员是PI，另外三项NSF赠款。五个外观中有三个具有良好的吸引力。这五个中的两个继续提交支持其研究领域的建议。在同一时期，特拉华州立大学（DSU）的一名INBRE资助的研究人员被授予NSF RUI，重点是病毒学研究。同样在DSU，一位INBRE资助的调查员也接受了另一所大学的职位，并在Inbre Eab和NCRR批准的情况下已将该项目的资金重定向给新的初级教职员工。第三名是Inbre资助的调查员不得不在第二年因生病停止他的计划。 Inbre Pi将重新分配资金。在克里斯蒂安娜（Christiana Care），一名调查员非常积极参与与UD和DBI研究人员的合作。这些合作导致了一些演讲和一份出版物。第二位调查员由于怀孕和分娩而决定离开近亲研究计划。第三名调查员接受了特拉华州以外的另一个医疗中心的职位。这些离职释放的一些资金已被重新定向，以与Nemours Biomedical Research建立新的合作，该研究正在制定活跃的生物医学转化研究计划。在第3年，Nemours将成为特拉华州近野的新合作伙伴。本科机构卫斯理学院的INBRE资金允许调查人员购买涉及本科生的夏季研究，并导致他们参加了几次全国会议，并在一份出版物上合着学生。尽管研究项目的第一阶段的直接资金将包括2006年6月，但特拉华州的近亲将继续通过核心中心费用摇动来支持调查人员。 Inbre网络中的研究人员可以安排免费使用核心仪器中心，包括生物信息学，生物成像，DNA测序和基因分型，质谱，微阵列，NMR，NMR以及蛋白质的产生和分析。新的特拉华州近亲研究招标特拉华州的近亲研究和行政领导才能在计划的未来三年内为提供给研究人员提供的赠款提供一个重要的机会。新的重点是癌症的基本和翻译工作，基于特拉华大学的优势，以及INBRE合作伙伴Christiana Care Health System和Nemours Biomedical Research的Helen F. Graham癌症中心的利益。新的重点并没有消除对其他类型的基础研究的考虑，而是提供了一些共同的基础，可以在近薪研究人员中建立更具凝聚力的社区。此外，决定开放向初级和高级调查人员提出建议的呼吁。这种方法将导致一群更强大的教师研究人员，他们可以在建立不断增长的生物医学研究能力的更广泛的目标中建立密切的合作并彼此受益。 2005年10月宣布了一轮近亲资助的赠款，并向特拉华州Inbre合作伙伴之间的院长和椅子发行，以广泛分配给教职员工。 INBRE RFP，说明和表格已发布在DBI网站上，DBI工作人员根据需要回答问题。新的Inbre赠款的设计类似于NIH R03的意图，并在32个月的时间内提供了16万美元的直接成本。提案于2005年12月提交。近亲研究委员会对提交的31项提案进行了审查并评分。审阅者使用以下一组加权标准来评分每个建议：»科学/生物医学功绩为50％»对特拉华州癌症倡议的贡献。 15％的本科参与10％�跨学科组成部分。 10％的机构间组成部分5％»使用核心中心5％»在2006年1月提出NIH赠款申请5％的潜力，委员会建议将13个选择发送给EAB以进行审查和批准。 2006年2月，EAB完成了批准过程。基于其在1＆2年度的INBRE计划中的经验，克里斯蒂安娜（Christiana Care）决定，它可以通过使用其一些资金来支持Nemours Biomedical Research的一项计划，从而最能从INBRE计划的目标中受益，并支持特拉华大学的一位初级教职员工，他们的研究与Helen F. Graham F. Graham F. Graham F. Graham F. Graham F. Graham，癌症中心的研究非常匹配。癌症中心医学主任尼古拉斯·佩特雷利（Nicholas Petrelli）博士将作为该项目的精神，由丹尼·伽利略（Deni Galileo）博士和特拉华大学生物科学系的助理教授主持。这项合作非常适合建立转化癌研究中心（CTCR）的更大计划。 CTCR将作为UD，DBI，Christiana Care和Nemours之间的虚拟实体启动。辛迪·法拉赫·卡森（Cindy Farach-Carson）博士是3年级的新教师之一，将担任CTCR的创始董事，并将CTCR的经常性资金包括在2007年州长的预算要求中。 of 3-D Cellular Models for Testing Anti-Neoplastic Agents Galileo, Deni ¿ Assistant Professor, Biological Sciences Autocrine Stimulation of Primary and Metastatic Brain Cancer Cells *(Project funded under the Christiana Care budget allocation) Johnston, Murray ¿ Professor, Chemistry and Biochemistry Mason, Robert ¿ Director, Cell Science Core, Nemours Proteomic Analysis of Apoptotic Mechanisms in Cancer坎德拉（Chandra）的坎巴海特（Kambhamettu前列腺癌特拉华州立大学：四个32个月的项目（加1个持续项目）：贝斯，塞缪尔·A·（Samuel A. Dragoljub生物学教授Pokrajac教授�计算机和信息科学助理教授，调查了无脊椎动物模型系统中的感官处理和学习的神经生物学，频道教授，应用数学和理论物理学的教授，对3-D乳腺表面的理论物理学分析在乳房X.禽肺的表达是人类卫斯理学院上呼吸道疾病的模型：三个一年的项目：D'Souza，Malcolm�教授，教授，糖基于酰基，磺酰基和磺胺硫酰基埃弗里特的化学范围凯瑟琳„ Del莱姆病和其他tick疾病的生物学分布副教授