Regulation of the plant metabolic network during stress

胁迫期间植物代谢网络的调节

基本信息

批准号：
BB/E024742/1
负责人：
Lee Sweetlove
金额：
$ 39.71万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FE024742%2F1
关键词：
Regulation plant metabolic network during

项目摘要

In the field, plants have to cope with environmental fluctuations which at their extremes cause stress to the plant. Under such stress conditions, the growth and development of the plant can be severely retarded. In an agricultural context, such sub-optimal growth conditions cause significant lowering of yields and are a major cause of variations in agricultural productivity from year to year. Furthermore, global climate changes are likely to dramatically exacerbate this problem. There is thus a pressing need to develop new varieties of staple crops that are more tolerant of abiotic stress conditions. Many modern crop species are the product of extensive breeding designed to maximise the biomass of the harvested organs. However, traits such as stress tolerance that are present in the wild progenitor species are often lost during the breeding process. Successful reintroduction of such traits will be dependent upon a detailed understanding of their molecular basis. One fo the key components of the response of plants to stress conditions is adaptive change in their metabolism. Understanding the nature of these metabolic reconfigurations is vital if we are to successfully generate new stress-resistant varieties of crops. Accordingly, the aim of the proposed work is to dissect the regulation of the metabolic network during oxidative stress in the model plant, Arabidopsis thaliana. Particular attention will be paid to discriminating between changes that occur at the level of gene expression and those that operate directly on proteins (so-called post-translational changes).

在现场，植物必须应对环境波动，从而极端给植物造成压力。在这种压力条件下，植物的生长和发育可能会严重阻碍。在农业背景下，这种亚最佳生长条件会大大降低产量，并且是农业生产率越来越多的主要原因。此外，全球气候变化可能会极大地加剧这个问题。因此，迫切需要开发新的主食作物，这些作物更宽容于非生物应力条件。许多现代农作物物种是广泛繁殖的产物，旨在最大化收获器官的生物量。但是，在繁殖过程中，野生祖细胞物种中存在的胁迫耐受性等特征通常会丢失。成功重新引入此类特征将取决于对它们的分子基础的详细理解。植物对压力条件的反应的关键组成部分是其新陈代谢的自适应变化。如果我们要成功地产生耐新的农作物种类，那么了解这些代谢重构的性质至关重要。因此，拟议工作的目的是在模型植物拟南芥中氧化应激期间剖析代谢网络的调节。将特别注意区分基因表达水平的变化以及直接在蛋白质上运作的变化（所谓的翻译后变化）。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress.

DOI：
10.1007/s11306-011-0296-1
发表时间：
2012-02
期刊：
METABOLOMICS
影响因子：
3.6
作者：
Lehmann, Martin;Laxa, Miriam;Sweetlove, Lee J.;Fernie, Alisdair R.;Obata, Toshihiro
通讯作者：
Obata, Toshihiro

Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings.

DOI：
10.1016/j.phytochem.2010.11.003
发表时间：
2011-07
期刊：
Phytochemistry
影响因子：
3.8
作者：
Toshihiro Obata;A. Matthes;Susanne Koszior;M. Lehmann;W. Araújo;R. Bock;L. Sweetlove;A. Fernie
通讯作者：
Toshihiro Obata;A. Matthes;Susanne Koszior;M. Lehmann;W. Araújo;R. Bock;L. Sweetlove;A. Fernie

Role of Lon1 protease in post-germinative growth and maintenance of mitochondrial function in Arabidopsis thaliana.

DOI：
10.1111/j.1469-8137.2008.02701.x
发表时间：
2009-02
期刊：
The New phytologist
影响因子：
0
作者：
Stamatis Rigas;G. Daras;Miriam Laxa;Nikolas Marathias;C. Fasseas;L. Sweetlove;P. Hatzopoulos
通讯作者：
Stamatis Rigas;G. Daras;Miriam Laxa;Nikolas Marathias;C. Fasseas;L. Sweetlove;P. Hatzopoulos