INVESTIGATIONS OF THERMAL EFFECTS IN PHOTODYNAMIC THERAPY TO TREAT SOLID TUMORS

光动力疗法治疗实体瘤的热效应研究

• 批准号: 7381381
• 负责人: PRADIP K BANDYOPADHYAY
• 金额: $ 9.96万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381381
• 关键词: INVESTIGATIONS; THERMAL; EFFECTS; PHOTODYNAMIC; THERAPY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project aims at the calibration of the theoretical Dynamic Thermal Damage Model (DTDM) and to determine the efficacy of the Laser Hyperthermia (LHT) treatment to treat superficial malignant tumors on an animal model (Balb/C mice). During the summer of 2004 (the duration of the subproject), we will primarily concentrate on the LHT work using a Diomed Diode laser. Thermal probes (IR Thermal Camera, Thermocouples) will yield the local temperature (fiber tip zone), the surface temperature and the average tumor temperature during laser hyperthermia therapy. Quantitative histology will be performed to quantify the thermal damage profile. The DTDM model will be calibrated in light of the predictions of the temperature field of the tumor, damage profile, and its comparison with the experimental damage data (histology). The validity of the model will be ascertained to predict the LHT damage. The major purpose of the DTDM is to calculate the amount of damage due to hyperthermia in combined LHT and PDT treatments.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该项目旨在校准理论动态热损伤模型（DTDM），并确定激光高温治疗（LHT）治疗以治疗动物模型（BALB/C小鼠）上表面恶性肿瘤的功效。在2004年夏季（副标理的持续时间），我们将主要使用二极管二极管激光器进行LHT工作。热探针（IR热摄像机，热电偶）将产生局部温度（纤维尖端区域），激光高温治疗期间的表面温度和平均肿瘤温度。将进行定量的组织学以量化热损伤曲线。 DTDM模型将根据肿瘤温度场，损伤概况的预测及其与实验损伤数据（组织学）的比较进行校准。该模型的有效性将确定以预测LHT损伤。 DTDM的主要目的是计算联合LHT和PDT处理中高温造成的损害量。