Modeling Individual Heterogeneity in the Alcohol Relapse Process

酒精复吸过程中的个体异质性建模

• 批准号: 7130641
• 负责人: Katie A Witkiewitz
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2007-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7130641
• 关键词: alcoholism /alcohol abuse; alcoholism /alcohol abuse therapy; behavioral /social science research tag; disease /disorder proneness /risk; drug /alcohol abstinence; human data; longitudinal human study; mathematical model; model design /development; motivation; outcomes research; relapse /recurrence; self concept; social support network; substance abuse related behavior

DESCRIPTION (provided by applicant): Approximately 17.6 million Americans meet criteria for alcohol abuse or dependence, and 12.5 percent of individuals who meet criteria for alcohol abuse or dependence (2.2 million Americans) will receive treatment for an alcohol problem. Of those who receive treatment, the majority of individuals will have at least one drink in the first 12-months following treatment. The proposed study aims to delineate patterns in post-treatment drinking during the first year following alcohol treatment. Data from Project MATCH, a multi-site investigation of alcohol treatment sponsored by the NIAAA, will be used to test the hypothesis that there is significant variability in the drinking behavior between individuals and within individuals across time. Secondary data analyses of the Project MATCH data will be conducted for three distinct purposes. The first goal of the proposed study will be to replicate previous research using latent growth mixture modeling to investigate common patterns and individual differences in trajectories of drinking after the initial post- treatment drink. The second goal is to describe the differences in drinking trajectories using a biopsychosocial model of relapse risk factors. The third goal is to quantify the complexity of the relapse process by extending the latent growth mixture models to analyze the behavior of individuals who transition in-and-out of abstinence. The goal of these analyses is to understand why and when individuals experience major shifts in drinking over time. The major aim of the proposed research is to provide an empirically-driven model of relapse that incorporates the individual variability and abrupt, discontinuous nature of the relapse process, as illustrated in theoretical and qualitative reports. The ultimate goal of this inquiry is to provide clinicians and their clients with a heightened awareness of risk factors that may predispose an individual to heavy drinking and those factors that increase the probability of transitioning from light-to-heavy drinking following treatment.

描述（由申请人提供）：大约 1,760 万美国人符合酒精滥用或依赖标准，并且符合酒精滥用或依赖标准的个人中 12.5%（220 万美国人）将接受酒精问题治疗。在接受治疗的人中，大多数人会在治疗后的前 12 个月内至少喝一次饮料。拟议的研究旨在描绘酒精治疗后第一年的治疗后饮酒模式。 MATCH 项目是一项由 NIAAA 赞助的酒精治疗多地点调查，该项目的数据将用于检验以下假设：随着时间的推移，个体之间和个体内部的饮酒行为存在显着差异。项目 MATCH 数据的二次数据分析将用于三个不同的目的。拟议研究的第一个目标是使用潜在生长混合物模型来复制之前的研究，以研究初次治疗后饮酒后饮酒轨迹的常见模式和个体差异。第二个目标是使用复发风险因素的生物心理社会模型来描述饮酒轨迹的差异。第三个目标是通过扩展潜在生长混合模型来分析戒断和戒断转变个体的行为，从而量化复发过程的复杂性。这些分析的目的是了解随着时间的推移，个人饮酒情况发生重大变化的原因和时间。拟议研究的主要目的是提供一个经验驱动的复发模型，该模型结合了个体变异性和复发过程的突然、不连续性质，如理论和定性报告中所示。本次调查的最终目标是让临床医生及其客户提高对可能导致个人酗酒的风险因素以及增加治疗后从轻度饮酒转变为重度饮酒的可能性的因素的认识。