INHERITABILITY OF CYP3A ACTIVITY

CYP3A 活性的遗传性

• 批准号: 7375661
• 负责人: grant R. wilkinson
• 金额: $ 2.64万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375661
• 关键词: INHERITABILITY; CYP3A; ACTIVITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The importance of a genetic determinant to a particular phenotype has classically been investigated by comparing variability between identical and fraternal twins. However, this approach obviously requires access to a twin population, which is problematic. An alternative approach has recently been suggested that uses inter- and intra-individual variability within a population of random, unrelated subjects (1-3). This is obviously a more accessible group for study. Interindividual variability in constitutive CYP3A activity is well-documented and there is evidence that individuals vary in their ability to up-regulate the enzyme when exposed to an inducing agent (4). The extent of genetic determination of such an increase in CYP3A activity is unknown. Specific Aim 1. To determine the magnitude of any genetic component to the constitutive and induced activity of CYP3A.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。通过比较相同的双胞胎和兄弟双胞胎之间的变异性，在经典研究了遗传决定因素对特定表型的重要性。但是，这种方法显然需要访问双胞胎人群，这是有问题的。最近已经提出了一种替代方法，该方法在随机，无关的受试者人群中使用个体间和个体内变异性（1-3）。显然，这是一个更容易访问的研究小组。 构成性CYP3A活性的个体变异性有充分记录，有证据表明，在暴露于诱导剂时，个体在上调酶的能力上有所不同（4）。 CYP3A活性增加的遗传确定程度尚不清楚。 具体目的1。确定CYP3A构成和诱导活性的任何遗传成分的幅度。