HYPERGLYCEMIA AND ADVERSE PREGNANCY OUTCOME (HAPO)

高血糖和不良妊娠结局 (HAPO)

• 批准号: 7378084
• 负责人: Patrick Catalano
• 金额: $ 0.44万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378084
• 关键词: HYPERGLYCEMIA; ADVERSE; PREGNANCY; OUTCOME; HAPO

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a federally funded prospective multi-center trial addressing the effect of hyperglycemia on pregnancy outcome (HAPO). The specific aims are to examine glucose tolerance in a large, heterogeneous, multinational, multi-cultural, ethnically diverse cohort of women in the third trimester of gestation with medical caregivers "blinded" to status of glucose tolerance, and to derive internationally acceptable criteria for the diagnosis and classification of gestational diabetes mellitus that are based on the specific relationships between maternal hyperglycemia and the risk of specific adverse outcomes. Pregnant women will be recruited in early gestation to participate. Those who give informed consent will provide historical and antenatal data and undergo metabolic evaluation (75g OGTT and measurement of hemoglobin A1C at approximately 28 weeks gestation). Cord blood will be collected at delivery for assessment of fetal beta-cell function; neonatal hyperglycemia will be determined at one hour of life; neonatal anthropometrics measured within 24 hours; and data on delivery and neonatal outcomes will be recorded.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这是一项由联邦资助的前瞻性多中心试验，涉及高血糖对妊娠结局的影响（HAPO）。具体目的是在妊娠三个月中以大型，异质，跨国，多元文化，种族多样性的妇女群体检查葡萄糖耐量，与医疗护理人员“蒙蔽”了葡萄糖耐受性的状态，并基于遗传性疾病的诊断和分类的遗传性疾病，以诊断遗传和分类是遗传性疾病的诊断，以遗传疾病的诊断和分类，这是遗传性疾病的诊断和分类。高血糖和特定不良结果的风险。孕妇将在妊娠早期招募参加。那些获得知情同意的人将提供历史和产前数据并接受代谢评估（75G OGTT和在妊娠约28周时对血红蛋白A1C的测量）。将在分娩时收集脐带血，以评估胎儿β细胞功能；新生儿高血糖将在生命的一个小时内确定；新生儿人为测量法在24小时内测量；以及有关交付和新生儿结果的数据。