ASSESSMENT OF ANABOLIC AGENTS AND EXERCISE IN BURNED CHILDREN

烧伤儿童的合成代谢药物和运动评估

• 批准号: 7378734
• 负责人: David N. Herndon
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378734
• 关键词: ASSESSMENT; ANABOLIC; AGENTS; EXERCISE; BURNED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Children with major burn injuries have increased energy needs for their healing bodies for up to one year post burn. During this hypermetabolic state they waste fat and muscle tissue and stop producing new bone. This can diminish their normal growth of childhood, leave them in a weakened state and prevent them from proper rehabilitation and reintegration back into society. Hypothesis: The use of a structured exercise training program and the use of anabolic drugs will decrease the hypermetabolic state following burn injury and quicken rehabilitation. Specific Aims and Procedures (summary): 1) A hypermetabolic state continues in burned children through the first year post burn causing muscle wasting, weakness, bone loss, decreased growth, decreased ability to fight infection, and increased scarring. 2) We hypothesize that by separate basic mechanisms, these catabolic-hypermetabolic responses may be ameliorated by therapeutic use of: An exercise program, Oxandrolone, Propranolol, Ketoconazole. Experimental Design (summary): Patients will be various groups of exercise and drugs beginning at 5 days after the first operation. Patients will be assessed at specific time intervals with a variety of tests and measurements (discharge, 6, 9, 12, 18, 24 months post burn). At the end of the study the groups will be compared to each other. Significance (summary): This study will have significant implications to improve treatment following a severe burn injury. It will provide information that may lead to improved methods of clinical care that will improve and hasten the recovery process.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。背景：重烧伤的儿童在烧伤后长达一年的愈合体能量需求增加。在这个多代谢状态下，它们浪费了脂肪和肌肉组织，并停止产生新的骨骼。这可以减少他们童年的正常成长，使他们处于弱势状态，并阻止他们适当地康复和重新融入社会。 假设：使用结构化运动训练计划和使用合成代谢药物将减少烧伤后的多代谢状态并加快康复。具体目的和程序（摘要）：1）烧伤后的第一年，烧伤儿童的多代谢状态持续，导致肌肉浪费，无力，骨质丧失，生长减少，降低与感染的能力以及增加疤痕。 2）我们假设通过单独的基本机制，可以通过治疗方法来改善这些分解代谢的甲甲代谢反应：锻炼程序，氧甲酮，普萘洛尔，酮康唑。 实验设计（摘要）：患者将是第一次手术后5天开始的各种运动和药物。将以特定时间间隔评估患者，并进行多种测试和测量（排出，燃烧后6、9、12、18、24个月）。在研究结束时，将相互比较小组。意义（摘要）：这项研究将对改善严重烧伤后的治疗产生重大影响。它将提供可能导致改进的临床护理方法的信息，从而改善和加速恢复过程。