INTEGRATIVE PATHWAYS TO HEALTH AND ILLNESS PROJECT 4: CONNECTING PSYCHOSOCIAL

健康与疾病的综合途径项目 4：连接心理社会

• 批准号: 7376147
• 负责人: MAXINE A WEINSTEIN
• 金额: $ 14.56万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376147
• 关键词: INTEGRATIVE; PATHWAYS; HEALTH; ILLNESS; PROJECT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to identify biomarkers that are individually, and in combination, associated with diverse forms of life challenges and psychological and social factors characterizing persons from young adulthood into old age. Cumulative adversity with limited compensating advantages is hypothesized to be reflected in multiple biological indicators of dysregulation. Conversely, the maintenance of high levels of well-being in the face of life's challenges is hypothesized to be reflected in biological indicators of high levels of functioning across multiple systems. Biomarker data collection will be carried out at 3 General Clinical Research Centers (at UCLA, University of Wisconsin, and Georgetown University) on a sub-sample of the MIDUS population (N=1350) and on a sub-sample of the Milwaukee African-American sample (N=200). The biomarkers reflect functioning of the hypothalamic-pituitary axis, the autonomic nervous system, the immune system, cardiovascular system, and metabolic processes. In addition to average/resting levels of such biomarkers, a laboratory cognitive and orthostatic challenge study is accompanied by assessments of salivary cortisol over time, heart-rate variability, and blood pressure dynamics. The quality of interpersonal relationships, the structuring of work experience and associated opportunities (or the lack thereof) for career advancement, a personal sense of purpose and growth, and the possession (or lack thereof) of effective strategies for management of diverse and often unanticipated life challenges are all phenomena that have been associated with biological responses, usually focused on one, or at most two, measures at a time. We will assess associations between responses on multiple biomarkers individually, and in combination, with individual challenges and complex profiles reflecting cumulative challenges and a diversity of psychosocial factors and health characteristics. The integration of evidence about psychosocial and biological interrelationships facilitates understanding of the factors associated with resilience and the maintenance of high levels of functioning. This, in turn, can provide a more rigorous foundation for multi-faceted health promotion programs in the future and facilitate understanding of the pronounced declines in disability among the elderly that have been occurring over the past two decades.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该项目的目的是确定与各种形式的生活挑战以及心理和社会因素相关的生物标志物，这些生物标志物是从成年到老年人的心理和社会因素。假设有限的补偿优势的累积逆境反映在多种生物学失调指标中。相反，假设面对生活挑战的高水平幸福感的维持可以反映在多个系统之间高水平功能的生物学指标中。生物标志物数据收集将在3个普通临床研究中心（加州大学洛杉矶分校，威斯康星大学和乔治敦大学）在Midus人口的子样本（n = 1350）和密尔沃基非洲 - 非洲 - 非洲子样本上进行。美国样本（n = 200）。生物标志物反映了下丘脑 - 垂体轴，自主神经系统，免疫系统，心血管系统和代谢过程的功能。除了这种生物标志物的平均水平/静息水平外，一项实验室的认知和体位挑战研究还伴随着对唾液皮质醇的评估，随着时间的流逝，心率变异性和血压动态。人际关系的质量，工作经验的结构和相关机会（或缺乏职业发展），个人的目标和成长感以及拥有（或缺乏的）有效管理多样化且经常意外的策略生活挑战都是与生物学反应相关的现象，通常一次集中在一个或最多两种措施上。我们将分别评估对多个生物标志物的反应，并结合个人挑战和复杂的概况，以反映累积挑战以及心理社会因素和健康特征的多样性。关于社会心理和生物学相互关系的证据的整合有助于理解与韧性相关的因素以及维持高水平的功能。反过来，这可以为将来的多方面健康促进计划提供更严格的基础，并促进对过去二十年来发生的老年人中明显下降的残疾下降的理解。