Neuropeptide Modulation of Aggression

攻击性的神经肽调节

• 批准号: 7116387
• 负责人: JOANNE Y YEW
• 金额: $ 4.88万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116387
• 关键词: Drosophilidae; aggression; amines; behavior test; behavioral /social science research tag; cell cell interaction; chemical structure function; genetically modified animals; immunocytochemistry; intermolecular interaction; molecular psychobiology; neuroanatomy; neurons; neuropeptides; neuroregulation; neurotransmitter transport; postdoctoral investigator; synapses

DESCRIPTION (provided by applicant): Aggression is a ubiquitous behavior important in social interactions such as the establishment of territory, access to food source, and mating success. Excessive aggression is also one symptom of some neurodegenerative disorders. Aminergic transmitters such as serotonin, dopamine, and norepinephrine (or its invertebrate homologue, octopamine) are one well-established category of neurotransmitter that play a role in aggression. In vertebrates, important roles for two families of peptides in aggression also have been established (AVP and GnRH peptide families) but these have been less well studied in invertebrate systems. With the use of behavioral analysis, immunocytochemistry to examine the co-localization of peptides and amines, and the GAL4/UAS system to genetically manipulate neuropeptide release, the role of peptides in aggression will be examined in a Drosophila model, which allows for the rigorous quantification of fighting behavior. The aims proposed here explore the possibility: (I) that neuropeptides are co-expressed with biogenic amines in the D. melanogaster nervous system; and (II) that the co-expressed peptides or peptides that interact with amine neurons play a role in regulating aggression.

描述（由申请人提供）：攻击性是一种普遍存在的行为，在社会互动中很重要，例如领土的建立、食物来源的获取和交配成功。 过度攻击也是一些神经退行性疾病的症状之一。血清素、多巴胺和去甲肾上腺素（或其无脊椎动物同系物章鱼胺）等胺能递质是一类公认的神经递质，在攻击行为中发挥作用。 在脊椎动物中，两个肽家族（AVP 和 GnRH 肽家族）在攻击行为中的重要作用也已确定，但在无脊椎动物系统中，这些肽家族的研究还较少。 通过使用行为分析、免疫细胞化学来检查肽和胺的共定位，以及 GAL4/UAS 系统来基因控制神经肽的释放，肽在攻击性中的作用将在果蝇模型中进行检查，该模型允许严格的研究战斗行为的量化。 这里提出的目标探讨了以下可能性：（I）神经肽与黑腹果蝇神经系统中的生物胺共表达； (II)共表达的肽或与胺神经元相互作用的肽在调节攻击性中发挥作用。