EFFECTS OF AGE ON LIMB ARTERIAL COMPLIANCE

年龄对四肢动脉顺应性的影响

• 批准号: 7378546
• 负责人: DAVID N PROCTOR
• 金额: $ 0.86万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378546
• 关键词: EFFECTS; AGE; LIMB; ARTERIAL; COMPLIANCE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many different types of changes in the vascular system may be at the heart of decreased blood vessel function with aging in humans. A key factor in this decrement in function appears to be changes in mechanical properties of the vessel walls and how they respond to blood pressure changes. Compliance of blood vessels is their distensibility in response to pressure changes inside them, i.e. how much the vessel walls move every time the heart beats. We have developed a software that can simultaneously record blood pressure tracings from a noninvasive blood pressure monitor and changes in calf volume from a noninvasive surface strain gauge every time the heart beats to derive whole calf compliance. This project will combine this technology with the method generally used to assess single vessel compliance using Doppler ultrasound and noninvasive blood pressure monitoring to compare whole calf compliance with that of the major artery feeding the calf vascular bed, the popliteal artery. This will be done to compare age-related changes in vessel compliance (from Doppler imaging and blood pressure tracings) with age-related changes in whole limb compliance (from surface strain gauge and blood pressure tracings) which reflects changes in the large vessels in the limb and the small vasculature that cannot be easily studied on its own. Measurements will be made during rest and moderate heating (about the temperature of a common sauna) of one calf and foot only to induce a locally higher blood flow without causing any cardiovascular distress or discomfort.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。血管系统中许多不同类型的变化可能是人类衰老的血管功能降低的核心。功能下降的关键因素似乎是容器壁的机械性能的变化以及它们如何应对血压变化。血管的依从性是它们响应内部压力变化的响应性，即每次心脏跳动时容器壁移动多少。我们已经开发了一个软件，可以同时记录非侵入性血压监测器的血压追踪，并每次心脏跳动以得出整个小腿依从性时，无创的表面应变量表的小腿体积变化。该项目将将这项技术与通常用于使用多普勒超声和非侵入性血压监测的单血管合规性的方法相结合，以将整个小腿与喂养小腿血管床的主要动脉（popliteal动脉）进行比较。这将是为了比较与年龄相关的船只依从性变化（从多普勒成像和血压跟踪）与年龄相关的整个肢体依从性（来自表面应变量表和血压跟踪）的变化，这反映了肢体中大容器的变化以及无法自行研究的小型脉管系统的变化。在休息和中等加热（大约是公共桑拿浴的温度）中，将进行一只小腿和脚的测量值，只是诱导局部更高的血液流动，而不会引起任何心血管遇险或不适。