PHARMACOKINETICS AND METABOLISM OF ANTIEPILEPTIC DRUGS IN ELDERLY PATIENTS

老年患者抗癫痫药物的药代动力学和代谢

• 批准号: 7375860
• 负责人: JAMES C. CLOYD
• 金额: $ 2.19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375860
• 关键词: PHARMACOKINETICS; METABOLISM; ANTIEPILEPTIC; DRUGS; ELDERLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to investigate the effect of advanced age on antiepileptic drug pharmacokinetics and metabolism. Selected elderly and adult male and female ambulant patients taking phenytoin (PHT or CBZ) as monotherapy for epilepsy will be evaluated. The patients will receive a portion of their oral dose of PHT as stable-labeled PHT given intravenously as 100 mg over 5 minutes (one time only). Stable-labeled PHT is NOT radioactive and exhibits the same kinetics and metabolism as unlabeled PHT. Blood samples and urine collections will be analyzed.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我们的目标是研究高级年龄对抗癫痫药药代动力学和代谢的影响。将评估选定的老年人和成年男性和女性救护车患者（PHT或CBZ）作为癫痫的单一疗法。患者将在5分钟内静脉注射100 mg（仅一次），将其一部分口服PHT作为稳定标记的PHT。稳定标记的PHT不是放射性的，并且表现出与未标记的PHT相同的动力学和代谢。将分析血液样本和尿液收集。