ASTHMA AND RHINOSINUSITIS

哮喘和鼻窦炎

• 批准号: 7378585
• 负责人: Anne E Dixon
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-09 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378585
• 关键词: asthma; rhinitis; sinusitis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A prospective cohort study to establish the relationship between the presence of asthma and markers of disease activity in the upper airway. There is a close pathophysiological relationship between the upper and lower airway disease that occurs in asthma. However, not all asthmatics report rhinitis/sinusitis: we anticipate those without symptoms may simply have subclinical disease. We will establish if upper airway disease is a characteristic of all asthmatics, by measuring inflammatory markers and functional changes in the upper airway of asthmatics with and without symptoms of upper airway disease. We will compare asthmatics to normal non-asthmatic subjects. We will also measure inflammatory markers and functional changes in the lower airway to determine if these measures correlate with markers of upper airway disease activity.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。一项前瞻性队列研究，旨在确定哮喘的存在与上呼吸道疾病活动标志物之间的关系。哮喘中发生的上呼吸道疾病和下呼吸道疾病之间存在密切的病理生理关系。然而，并非所有哮喘患者都会报告鼻炎/鼻窦炎：我们预计那些没有症状的患者可能只是患有亚临床疾病。我们将通过测量有或没有上呼吸道疾病症状的哮喘患者上呼吸道的炎症标志物和功能变化来确定上呼吸道疾病是否是所有哮喘患者的特征。我们将比较哮喘患者与正常非哮喘受试者。我们还将测量下呼吸道的炎症标志物和功能变化，以确定这些测量值是否与上呼吸道疾病活动的标志物相关。