EFFECT OF DELTA9 TETRAHYDROCANNABINOL ON CEREBRAL ACTIVITY MEASURED BY MRI

Delta9 四氢大麻酚对 MRI 测量的大脑活动的影响

• 批准号: 7375057
• 负责人: ALAN S BLOOM
• 金额: $ 0.71万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375057
• 关键词: EFFECT; DELTA9; TETRAHYDROCANNABINOL; CEREBRAL; ACTIVITY; EFFECT; DELTA9; TETRAHYDROCANNABINOL; CEREBRAL; ACTIVITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis to be tested by this project is that THC produces characteristic changes in the activity of the human brain, both at rest and during the performance of cognitive and perceptual-motor tasks that are measurable using functional magnetic resonance imaging (fMRI) measures of blood flow and neuronal activity. We further propose that the behavioral and physiological effects of THC and marijuana in humans are due to a unique pattern of brain regions engaged following acute drug administration, and that the two will be related in time and magnitude. We have completed studies in the following areas: We have determined the effects of 3 doses of THC on brain activity, which included findings of a dose-dependent changes in activity in several brain regions and that THC administration decreased brain activation by a series of cognitive and motor tasks. In addition we have measured in real-time, the subjective effects of THC in subjects undergoing scanning and used them to investigate changes in brain activity associated with them.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该项目要检验的总体假设是，THC在人脑活动的活动中以及在认知和感知运动任务的性能中都会产生特征变化，这些任务是使用功能磁共振成像（FMRI）测量的血液流动和神经元活性的测量方法。我们进一步建议，THC和大麻在人类中的行为和生理作用是由于急性药物给药后参与大脑区域的独特模式，并且两者将在时间和大小上相关。我们已经在以下领域完成了研究：我们确定了3剂THC对大脑活动的影响，其中包括对几个大脑区域活动剂量依赖性变化的发现，而THC给药通过一系列认知和运动任务降低了大脑的激活。此外，我们已经实时测量了THC在接受扫描的受试者中的主观影响，并用它们来研究与它们相关的大脑活动的变化。