GASTRIC BYPASS EFFECTS ON SLEEP & GLUCOSE REG

胃绕道术对睡眠的影响

• 批准号: 7378613
• 负责人: John C Alverdy
• 金额: $ 1.05万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378613
• 关键词: glucose; glucose tolerance; reduction; sleep; surgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clinical observations suggest that patients sleep better and feel less sleepy a few days after gastric bypass, ie. Before significant weight reduction. The mechanism is not known. The proposed studies will test the hypotesis that improved glucose tolerance is the mechanism underlying rapid effect of gastric bypass on sleep and sleepiness. Patients undergoing briatric surgery will be studied during two separate 8-day inpatient admissions, one before surgery and one after surgery. On both occasions, dietary intake will be limited to 1,200 Kcal and strictly controlled. Sleep, sleepiness and parameters of glucose tolerance will be assessed at the beginning and at the end of both study p

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。临床观察结果表明，胃旁路几天后，患者睡得更好，感觉较少。在大量减轻重量之前。该机制尚不清楚。拟议的研究将测试改善葡萄糖耐受性的低调是胃旁路对睡眠和嗜睡的快速作用的基础机制。在两次独立的8天住院入院中，将研究接受幼体手术的患者，一名在手术前，一名手术后。在这两种情况下，饮食摄入量都将限制为1200 kcal并严格控制。葡萄糖耐量的睡眠，嗜睡和参数将在两项研究的开始和结束时进行评估