COMPENSATORY CHANGES IN RENAL SENESCENCE

肾脏衰老的代偿性变化

• 批准号: 7375252
• 负责人: BRYAN David MYERS
• 金额: $ 1.47万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375252
• 关键词: COMPENSATORY; CHANGES; RENAL; SENESCENCE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to compare the kidney function in the aged versus the young, following uninephrectomy (surgical removal of one kidney). We plan to compare kidney function in young and aged kidney transplant donors. In addition, we plan to study young and aged patients who have undergone uninephrectomy as a result of hypernephroma in the removed kidney. It is well known that humans can adapt to the loss of one kidney, through compensatory hypertrophy of the remaining kidney as it adapts to restore renal function. Past investigators have suggested that kidney function declines with age, but recent literature suggests that not all humans are subject to this decline. Furthermore, it is unknown whether the aged kidney donor can undergo compensation, in the remaining kidney, to the same degree as the young kidney donor after uninephrectomy: in other words, can the aged kidney compensate as well as the young kidney, following removal of the other kidney. Very few trials have reported on this, and amongst these trials, there are contradictory findings. We wish to investigate kidney function (insulin clearance) before and after kidney donation in healthy living donors, with the purpose of comparing the findings in the young donors versus the old donors. Because the number of aged (60+ yrs) kidney donors is small, we will include subjects who have undergone uninephrectomy due to hypernephroma, and study old and younger patients in this population as well.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是比较单纯切除术（手术去除一个肾脏）后，比较年龄与年轻人的肾功能。我们计划比较年轻和老年肾脏移植供体中的肾脏功能。此外，我们计划研究因去除的肾脏中肾素瘤而进行单次切除术的年轻和老年患者。众所周知，人类可以通过剩余肾脏的代偿肥大来适应肾功能的损失。过去的研究人员建议肾功能随着年龄的增长而下降，但最近的文献表明，并非所有人类都会遭受这种下降。此外，尚不清楚老年肾脏供体在剩下的肾脏中是否可以与单次肾脏切除术后的年轻肾脏供体相同的程度：换句话说，老年肾脏能否补偿和年轻的肾脏，在去除其他肾脏后。很少有关于此的试验，在这些试验中，有矛盾的发现。 我们希望在健康的活捐赠者中肾脏捐赠之前和之后研究肾脏功能（胰岛素清除），目的是比较年轻捐助者的发现与老捐助者的发现。由于年龄（60岁以上）肾脏供体的数量很少，因此我们将包括因甲脂瘤而进行单次切除术的受试者，并研究该人群中的老年和年轻患者。