INSULIN RESISTANCE: IT'S ROLE IN WEIGHT LOSS AND CARDIOVASCULAR RISK

胰岛素抵抗：它在减肥和心血管风险中的作用

• 批准号: 7375200
• 负责人: TRACEY MCLAUGHLIN
• 金额: $ 22.77万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375200
• 关键词: INSULIN; RESISTANCE; ROLE; WEIGHT; LOSS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central focus of this study is on the importance of resistance to insulin-mediated glucose disposal and compensatory hyperinsulinemia in modulation of insulin resistance (IR) and its role in weight loss and cardiovascular risk. The purpose of this study is to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals. In addition, the impact of hyperinsulinemia on risk for coronary heart disease will be addressed. Both non-diabetics and diabetics will be studied. This protocol includes several active arms of a study designed to evaluate the impact of macronutrient composition on: 1) ability to lose weight 2) reduction in cardiovascular risk, among overweight or obese individuals with IR. Total subjects expected for entire study Screening: 300-400 Enrollment: Arm 1: obese nondiabetic: 60 Arm 2: obese diabetic diet only: 36 Arm 3: obese diabetic monotherapy: 45 Arm 4: overweight nondiabetic: 20 Arm 5: obese Southeast Asian women: 20 Adipose tissue biopsy substudy: 30

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。本研究的重点是胰岛素介导的葡萄糖处理抵抗和代偿性高胰岛素血症在调节胰岛素抵抗（IR）中的重要性及其在减肥和心血管风险中的作用。本研究的目的是确定肥胖个体的胰岛素抵抗/高胰岛素血症与减肥能力之间的关系。此外，还将讨论高胰岛素血症对冠心病风险的影响。非糖尿病患者和糖尿病患者都将受到研究。 该方案包括一项研究的几个活跃部分，旨在评估常量营养素成分对以下方面的影响：1) 减肥能力 2) 降低超重或肥胖 IR 患者的心血管风险。整个研究预计筛选的受试者总数：300-400 入组： 第 1 组：肥胖非糖尿病：60 第 2 组：仅肥胖糖尿病饮食：36 第 3 组：肥胖糖尿病单药治疗：45 第 4 组：超重非糖尿病：20 第 5 组：肥胖东南亚人女性：20 脂肪组织活检亚组研究：30