EVALUATION OF DENTIFRICE IN-SITU USING AN OCCLUSAL CARIES MODEL

使用咬合面龋齿模型评估牙膏原位

• 批准号: 7377045
• 负责人: SHERRY R TIMMONS
• 金额: $ 2.84万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377045
• 关键词: EVALUATION; DENTIFRICE; SITU; USING; OCCLUSAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dental caries remains one of the most prevalent diseases in the Western world. The widespread use of fluoride has helped to reduce the severity of the disease as well as changing the pattern of the disease process. It is now recognized that the occlusal tooth surface accounts for more disease than the smooth surface. Previous caries models used "smooth surfaces" since they have a more standard morphology and are easier to study. The morphology of the grooves and fissures in the occlusal surface provides an additional risk factor for the caries process. To more fully understand the disease process in these susceptible surfaces, an occlusal caries model that includes an artificial fissure needs to be developed. The aim of this study will be to test a model that combines a traditional, smooth surface crown model with an occlusal surface component for in situ situations. The occlusal component will have two centrally located, parallel troughs of equal dimensions placed on the enamel surface to mimic the occlusal groove architecture of normal tooth morphology. The crown will also have traditional enamel and root sections placed on the interproximal surface to replicate normal smooth surface tooth morphology.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。龋齿仍然是西方世界最流行的疾病之一。氟化物的广泛使用有助于减轻疾病的严重程度并改变疾病过程的模式。现在人们认识到，咬合的牙齿表面比光滑的表面造成更多的疾病。以前的龋齿模型使用“光滑表面”，因为它们具有更标准的形态并且更容易研究。咬合面的凹槽和裂隙的形态为龋齿过程提供了额外的风险因素。为了更全面地了解这些易受影响表面的疾病过程，需要开发包含人工裂隙的咬合龋模型。本研究的目的是测试一个模型，该模型将传统的光滑表面牙冠模型与咬合表面组件相结合，用于现场情况。咬合组件将具有两个位于牙釉质表面的位于中心的、尺寸相等的平行槽，以模仿正常牙齿形态的咬合槽结构。牙冠还将传统的牙釉质和牙根部分放置在邻间表面上，以复制正常光滑表面的牙齿形态。