OXIDATIVE STRESS IN AORTIC ANEURYSM

主动脉瘤的氧化应激

• 批准号: 7377037
• 负责人: Neal L Weintraub
• 金额: $ 0.03万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377037
• 关键词: OXIDATIVE; STRESS; AORTIC; ANEURYSM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abdominal aortic aneurysms (AAA) occur in up to 9% of persons >65 years of age. Surgical techniques to repair AAA carry significant risks, and there is no particularly effective medical therapy. The highly inflammatory nature of AAA leads to (1) an increase in the formation of ROS, and (2) a decrease in the levels of protective antioxidants in these patients. These findings suggest that oxidative stress is enhanced and may play a role in the pathogenesis of AAA in humans. While our long-term hypothesis is that effective antioxidant therapy can attenuate AAA growth and its consequences (i.e., rupture) in patients with AAA, the purpose of this pilot project is to identify a clinically effective antioxidant regimen that reduces oxidative stress in AAA patients.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。 65 岁以上的人中，高达 9% 的人会发生腹主动脉瘤 (AAA)。修复 AAA 的手术技术存在很大风险，并且没有特别有效的药物治疗方法。 AAA 的高度炎症性质导致 (1) ROS 形成增加，(2) 这些患者的保护性抗氧化剂水平降低。这些发现表明，氧化应激增强，可能在人类 AAA 的发病机制中发挥作用。虽然我们的长期假设是有效的抗氧化疗法可以减轻 AAA 患者的 AAA 生长及其后果（即破裂），但该试点项目的目的是确定一种临床有效的抗氧化疗法，以减少 AAA 患者的氧化应激。