TARGETED FORTIFICATION OF BREAST MILK FED TO PREMATURE INFANTS

有针对性地强化早产儿母乳喂养

• 批准号: 7377020
• 负责人: EKHARD E ZIEGLER
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377020
• 关键词: TARGETED; FORTIFICATION; BREAST; MILK; FED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast milk fed to very-low-birth-weight (VLBW) infants needs to be fortified with protein, mineral and vitamins because concentrations of these nutrients are insufficient to meet the high needs of VLBW infants. The aim of fortification is to raise nutrient concentrations to such levels that nutrient needs are met at usual feeding volumes. Fortification also includes the addition of energy in the form of carbohydrate and fat, with the objective of increasing the caloric density of fortified milk in order to reduce the volume of feedings necessary to achieve adequate energy intakes. The purpose of the study is to determine whether a new method of fortifying breast milk fed to VLBW babies leads to improved nutrient intake and growth. This study will test the hypotheses that targeted fortification is feasible; that targeted fortification achieves higher intakes of protein and calories than standard fortification; and that targeted fortification leads to higher weight gain than standard fortification.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。极低出生体重 (VLBW) 婴儿的母乳需要强化蛋白质、矿物质和维生素，因为这些营养素的浓度不足以满足 VLBW 婴儿的高需求。强化的目的是将营养物质浓度提高到以通常的饲喂量满足营养需求的水平。强化还包括添加碳水化合物和脂肪形式的能量，目的是增加强化奶的热量密度，以减少实现足够能量摄入所需的喂养量。 该研究的目的是确定一种强化极低出生体重婴儿母乳的新方法是否可以改善营养摄入和生长。这项研究将检验有针对性的防御措施是否可行的假设；有针对性的强化比标准强化实现了更高的蛋白质和卡路里摄入量；与标准强化相比，有针对性的强化会导致更高的体重增加。