NEURAL SUBSTRATES OF CIGARETTE SMOKING AND RELATED BEHAVIORS

吸烟及相关行为的神经基质

• 批准号: 7377003
• 负责人: ANTOINE BECHARA
• 金额: $ 0.23万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377003
• 关键词: NEURAL; SUBSTRATES; CIGARETTE; SMOKING; RELATED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Functional neuroimaging studies have pointed to a neural network of limbic and paralimbic structures that subserve the behavioral processes of addiction to drugs of abuse, including nicotine. This neural network includes the orbitofrontal cortex, anterior cingulate, insular cortices, the amygdala, and the striatum (dorsal striatum and ventral striatum or nucleus accumbens). However, no work in humans has addressed how damage to different components of this neural network in humans will impact the craving, subjective feeling of drug administration, and active seeking of drugs. Nor any of the human studies to date has asked which, if any, of these components is critically necessary for the maintenance of addiction to drugs. This proposal will take advantage of our unique University of Iowa Department of Neurology Patient Registry to begin addressing some of these important issues in patients addicted to nicotine. This project will allow us to understand the brain mechanisms by which environmental exposure to cigarette smoke alters urge and related subjective and physiological parameters that may promote uncontrolled use and relapse. These processes will be studied in both lesioned subjects and in neurologically intact subjects.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。功能性神经影像学研究指出，边缘和旁边缘结构的神经网络促进了对包括尼古丁在内的滥用药物成瘾的行为过程。该神经网络包括眶额皮质、前扣带皮层、岛叶皮质、杏仁核和纹状体（背侧纹状体和腹侧纹状体或伏隔核）。然而，目前还没有针对人类的研究表明，人类神经网络不同组成部分的损伤将如何影响对药物的渴望、主观感觉以及对药物的主动寻求。迄今为止，也没有任何人体研究询问这些成分中的哪一种（如果有的话）对于维持药物成瘾是至关重要的。该提案将利用我们独特的爱荷华大学神经病学系患者登记处来开始解决尼古丁成瘾患者的一些重要问题。该项目将使我们能够了解暴露于香烟烟雾的环境中改变冲动以及相关主观和生理参数的大脑机制，这些参数可能会促进不受控制的使用和复吸。这些过程将在受损受试者和神经完整受试者中进行研究。