GENETIC POLYMORPHISMS IN CHILDREN WITH CONGENITAL HEART DISEASE

先天性心脏病儿童的基因多态性

• 批准号: 7376472
• 负责人: Robert E Shaddy
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376472
• 关键词: DNA; G protein; adrenergic receptor; beta adrenergic receptor; biopsy; blood; children; genes; genetics; heart; single nucleotide polymorphism; skin; syndrome

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine the frequency of specific beta-adrenergic receptor, G-protein, Alpha 2-adrenergic receptor, Erk2 and H-Ras single nucleotide polymorphisms (SNP's) in a sample of children with congenital heart disease, specifically hypoplastic left heart syndrome (HLHS) and d-transposition of the great arteries (dTGA). Specific SNP's will be correlated with post-operative inotropic requirements, measures of ventricular function, and mortality. Blood will be drawn or skin biopsies will be obtained (infants) from study patients for the purpose of DNA isolation and determination of SNP's of the above-stated genes.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。 The purpose of this study is to examine the frequency of specific beta-adrenergic receptor, G-protein, Alpha 2-adrenergic receptor, Erk2 and H-Ras single nucleotide polymorphisms (SNP's) in a sample of children with congenital heart disease, specifically hypoplastic left heart syndrome (HLHS) and d-transposition of the great arteries (dTGA).特定的SNP将与术后肌力肌功能要求，心室功能和死亡率相关。将抽血或从研究患者那里获得（婴儿）的皮肤活检，以隔离和测定上述基因的SNP。