EFFECTS OF ST JOHN?S WORT ON LEVONORGESTREL/EMERGENCY CONTRACEPTION

圣约翰草对左炔诺孕酮/紧急避孕的影响

• 批准号: 7376478
• 负责人: PATRICIA MURPHY
• 金额: $ 3.56万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376478
• 关键词: St Johns wort; aging; clinical trials; contraceptives; enzymes; liver; metabolism; pregnancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate the effects of a common herbal remedy, St. John's Wort (Hypericum perforatum), on metabolism of levonorgestrel in a dosing regimen for emergency contraception. Emergency contraception, if taken soon after unprotected intercourse, prevents pregnancy. St. John¿s Wort induces the P450 enzyme system in the liver, and may cause increased metabolism of contraceptive steroids used as emergency contraception. This will be a randomized, blinded, clinical trial of four groups of reproductive-aged women to assess the potential interaction between St. John¿s Wort and levonorgestrel.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一，该子项目和研究者 (PI) 可能已从其他 NIH 来源获得主要资助，因此可以在其他 CRISP 机构中得到体现。列出的是该中心，该中心不一定是研究者的机构。本研究将评估一种常见草药圣约翰草（贯叶连翘）对左炔诺孕酮代谢的影响。紧急避孕的剂量方案，如果在无保护性交后立即服用，可以防止怀孕。圣约翰草会诱导肝脏中的 P450 酶系统，并可能导致用作紧急避孕的避孕类固醇的代谢增加。这将是一项针对四组育龄妇女的随机、盲法临床试验，以评估圣约翰草之间的潜在相互作用。约翰·凯麦芽汁和左炔诺孕酮。