IMMUNOGENETICS OF POLYGLANDULAR FAILURE

多腺体衰竭的免疫遗传学

• 批准号: 7374328
• 负责人: GEORGE S EISENBARTH
• 金额: $ 0.49万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-24 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374328
• 关键词: autoantibody; autoimmunity; clinical research; glucose; insulin; pancreatic islet function; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall protocol analyzes expression of autoantibodies for a large number of patients and their relatives with autoimmunity. The clinical research center portion of the protocol allows the metabolic evaluation of a much smaller group of individuals expressing 21-hydroxylase autoantibodies to rule of the presence of Addison's disease and to prospectively define the progression to overt Addison's disease and in addition for individuals expressing anti-islet autoantibodies, glucose and insulin secretion is evaluated, to diagnose diabetes and to follow progression to diabetes in those at risk.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。总体方案分析了许多患有自身免疫性的患者及其亲戚的自身抗体表达。该方案的临床研究中心部分允许对一组表达21-羟化酶自身抗体的个体进行代谢评估，以统治艾迪生氏病的存在，并前瞻性地定义了对明显的艾迪生氏病的进展，以及表达抗疾病自动抗体，gllucos和胰岛素的疾病的疾病和诊断的抗疾病的抗体自动抗体和胰岛素疾病的疾病以及诊断的疾病的评估。