CRANBERRY FOR PREVENTION OF UTI

蔓越莓预防尿路感染

• 批准号: 7379356
• 负责人: Thomas M Hooton
• 金额: $ 1.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379356
• 关键词: CRANBERRY; PREVENTION; UTI

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Repeated urinary tract infections (UTIs) are a very common problem in young healthy women. One possible but unproven method of preventing repeat UTIs is by drinking cranberry juice cocktail. The purpose of this study is to determine what effect different amounts of cranberry juice cocktail have on the urine's ability to prevent bacteria from sticking to bladder cells, which is how cranberry juice cocktail is thought to possibly prevent UTIs. This will be accomplished by assigning women randomly (like flipping a coin) to drink different amounts of artificially sweetened cranberry juice cocktail (2 oz to 16 oz), and then studying their urines in the laboratory to see whether they reduce the "stickiness" of bacteria to bladder cells. The study is done twice for each person, once with food and once on an empty stomach. Participants are asked to collect their urine at 4,8,12 and 24 hour intervals after they drink the cranberry juice. Premenopausal women 18-45 years of age with at least one UTI in the past year are eligible for the study. Participants can have no antibiotic use in the past 7 days prior to enrollment and no UTI symptoms, such as burning on urination. In addition, they cannot be pregnant, have an allergy to cranberry juice or have a history of kidney stones. Women enrolled will be asked to avoid all foods containing cranberries (other than the study product), blueberries and lingonberries.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。重复的尿路感染（UTI）是年轻健康女性的一个非常普遍的问题。一种防止重复尿路的一种可能但未经证实的方法是喝蔓越莓汁鸡尾酒。这项研究的目的是确定不同量的蔓越莓汁鸡尾酒对尿液防止细菌粘附到膀胱细胞的能力的影响，这就是蔓越莓汁鸡尾酒的方式可能会预防UTI。这将通过随机分配（例如翻转硬币）来喝不同量的人工甜味蔓越莓汁鸡尾酒（2盎司至16盎司）来实现这一目标，然后在实验室研究尿液，以查看她们是否减少了“粘性”细菌到膀胱细胞。该研究对每个人进行了两次，一次用食物，一次空腹进行。饮用蔓越莓汁后，要求参与者以4,8,12和24小时的间隔收集尿液。过去一年中至少有一个UTI的18-45岁的绝经前妇女有资格进行这项研究。参与者在入学前的过去7天内无法使用抗生素，并且没有UTI症状，例如排尿燃烧。此外，他们不能怀孕，对蔓越莓汁过敏或有肾结石病史。将要求入学的妇女避免所有含有蔓越莓（研究产品除外），蓝莓和ling子的食物。