TRIAL OF AN ENCAPSULATED GINGER STANDARDIZED TO 5%-6-GINGEROLS

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• 批准号: 7376588
• 负责人: SUZANNA M. ZICK
• 金额: $ 7.26万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376588
• 关键词: blood; family planning; fasting; hospitals; university

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we want to find the highest dose of ginger that a person can take before they have a side-effect. We will check how safe ginger is at all doses. Also, we will look at how ginger can be detected in blood after it is taken as a pill. In our study, we will test six different doses of ginger. There will be three people at each dose, plus six people at the highest dose. The six doses of ginger are 100 mg, 250 mg, 500 mg, 1000 mg, 1500 mg, and 2000 mg. If one person has a bad side-effect to ginger we will stop the study. The ginger dose that is lower than the one that caused the bad side-effect will be the highest dose of ginger that is safe. If one person has a small side-effect to ginger three more people will be added to the study at the same dose that caused the small side-effect. Also, if two people have a small side-effect at the same dose of ginger we will stop the study. The ginger dose that caused the small side-effect will be highest dose of ginger that is safe. People who can be in this study need to be at least 18 years old, have no illnesses and taking no medications, except for birth control. Before starting the study everyone who is in the study will sign a consent form, which explains what will happen during the study. Everyone in the study will stay at the University of Michigan Hospital for 10 hours after taking their ginger dose. You must fast for 8 hours before your 10 hour stay at the University of Michigan Hospital. One tablespoon of blood will be taken before the ginger dose and then at 15 minutes, 30 minutes, forty-five minutes, one hour, two hours, four hours, six hours, eight hours, and ten hours after taking the ginger dose. Also, everyone in the study will return to the hospital at 24, 48 and 72 hour to have their blood drawn.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。在这项研究中，我们希望找到一个人在副作用之前可以服用的最高剂量的生姜。我们将检查姜的安全性。另外，我们将研究如何在将其视为药丸后如何在血液中检测到姜。 在我们的研究中，我们将测试六种不同剂量的生姜。每个剂量都会有三个人，加上六个人的最高剂量。六剂生姜为100毫克，250毫克，500毫克，1000毫克，1500毫克和2000毫克。如果一个人对生姜的副作用不好，我们将停止研究。比导致不良副作用的姜剂量低的剂量是安全的姜剂量。如果一个人对生姜的副作用很小，则将以相同的剂量添加三个人。另外，如果两个人在同一剂量的生姜处具有小的副作用，我们将停止研究。引起小副作用的生姜剂量将是安全的最高剂量的生姜。 可以参加这项研究的人至少需要18岁，没有疾病，没有服用药物，除了节育。在开始研究之前，每个正在研究的人都将签署同意书，这说明了研究期间将会发生什么。 接受姜剂量后，研究中的每个人都会在密歇根大学医院停留10个小时。您必须在10小时留在密歇根大学医院之前禁食8个小时。服用姜剂量后，将在生姜剂量之前抽一汤匙的血液，然后在15分钟，30分钟，15分钟，一小时，四小时，六个小时，八个小时和十个小时时取出一汤匙的血液。此外，研究中的每个人都将在24、48和72小时回到医院，以吸血。