MRI DETERMINED BONE MARROW EDEMA IN OSTEOARTHRITIS OF THE KNEE

MRI 确定膝骨关节炎的骨髓水肿

• 批准号: 7376532
• 负责人: MARYFRAN R SOWERS
• 金额: $ 0.56万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376532
• 关键词: bone; bone marrow; edema; joints; knee; pain

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Though osteoarthritis (OA) is highly prevalent and includes compromised articular cartilage, subchondral bone, and synovium, pain as a symptom drives much of the disability, requirement for therapy and health care costs. There is a very limited understanding of how OA pain patterns are related to tissue in the joint, particularly since cartilage does not have nerve endings that are required to feel pain. However, a better understanding of the processes leading to the development and perpetuation of painful OA, in relation to joint structures, is likely to extend the number of options for intervention. This application contributes to a series of studies to determine if pain in OA is associated with bone marrow edema (BME), observable only with magnetic resonance imaging (MRI). It is proposed that this "edema" or fluid accumulation increases the pressure within bone in joints and activates pain receptors in the bone. It is further proposed that BME comes, in part, from mal-distributed weight-bearing forces on the knee and is most likely initiated or perpetuated by obesity. Currently, BME is evaluated qualitatively based on a 3-level determination of the size of a lesion. We propose to develop a quantitative approach to measure BME and describe the reproducibility of that approach with MRI.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。尽管骨关节炎（OA）高度普遍，包括关节软骨，软骨下骨和滑膜下的损害，但作为症状的疼痛促进了许多残疾，治疗和医疗保健费用的需求。人们对OA疼痛模式与关节中组织的关系有非常有限的了解，特别是因为软骨没有感到疼痛所需的神经结尾。但是，更好地理解导致痛苦的OA发展和延续的过程，与关节结构有关，可能会扩大干预措施的数量。该应用有助于一系列研究，以确定OA中的疼痛是否与骨髓水肿（BME）相关，仅与磁共振成像（MRI）可观察到。有人提出，这种“水肿”或液体的积累会增加关节中骨骼的压力，并激活骨骼中的疼痛受体。进一步提出，BME部分来自膝盖上的MAL分布体重力，很可能是由肥胖引发或永久存在的。当前，基于病变大小的3级确定，对BME进行定性评估。我们建议开发一种定量方法来测量BME并用MRI来描述该方法的可重复性。