MRI DETERMINED BONE MARROW EDEMA IN OSTEOARTHRITIS OF THE KNEE

MRI 确定膝骨关节炎的骨髓水肿

• 批准号: 7376532
• 负责人: MARYFRAN R SOWERS
• 金额: $ 0.56万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376532
• 关键词: bone; bone marrow; edema; joints; knee; pain

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Though osteoarthritis (OA) is highly prevalent and includes compromised articular cartilage, subchondral bone, and synovium, pain as a symptom drives much of the disability, requirement for therapy and health care costs. There is a very limited understanding of how OA pain patterns are related to tissue in the joint, particularly since cartilage does not have nerve endings that are required to feel pain. However, a better understanding of the processes leading to the development and perpetuation of painful OA, in relation to joint structures, is likely to extend the number of options for intervention. This application contributes to a series of studies to determine if pain in OA is associated with bone marrow edema (BME), observable only with magnetic resonance imaging (MRI). It is proposed that this "edema" or fluid accumulation increases the pressure within bone in joints and activates pain receptors in the bone. It is further proposed that BME comes, in part, from mal-distributed weight-bearing forces on the knee and is most likely initiated or perpetuated by obesity. Currently, BME is evaluated qualitatively based on a 3-level determination of the size of a lesion. We propose to develop a quantitative approach to measure BME and describe the reproducibility of that approach with MRI.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。尽管骨关节炎 (OA) 非常普遍，并且包括关节软骨、软骨下骨和滑膜受损，但疼痛作为一种症状导致了大部分残疾、治疗需求和医疗保健费用。对于 OA 疼痛模式与关节组织之间的关系，人们的了解非常有限，特别是因为软骨没有感觉疼痛所需的神经末梢。然而，更好地了解导致疼痛性骨关节炎的发生和持续的过程（与关节结构相关）可能会增加干预选择的数量。该应用有助于一系列研究，以确定 OA 疼痛是否与骨髓水肿 (BME) 相关，而骨髓水肿 (BME) 只能通过磁共振成像 (MRI) 观察到。有人提出，这种“水肿”或液体积聚会增加关节骨内的压力，并激活骨中的疼痛感受器。进一步提出，BME 部分源于膝盖上分布不均的负重力，并且很可能是由肥胖引起或持续的。目前，BME 是根据病变大小的 3 级确定进行定性评估的。我们建议开发一种定量方法来测量 BME 并描述该方法与 MRI 的可重复性。