NEUROHUMORAL MECHANISMS IN GERIATRIC HYPERTENSION: ROLE OF ALDOSTERONE

老年高血压的神经体液机制：醛固酮的作用

• 批准号: 7376499
• 负责人: Mark A Supiano
• 金额: $ 2.45万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376499
• 关键词: aldosterone; blood pressure; blood vessels; geriatrics; hypertension; role

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if increased levels of a hormone produced in the adrenal gland, aldosterone, plays a part in the increase in blood pressure that is common as people get older. The study is designed to test for interactions between aldosterone and other factors known to be important in high blood pressure in older people. These factors are stiffness of blood vessels, the activity of the sympathetic nervous system (the part of the nervous system that produces the chemical norepinephrine that controls heart rate and blood pressure), insulin, and a relaxing factor produced by blood vessels (nitric oxide). These systems will be tested at the beginning of the study, and again six months later following treatment with one of two medications that are used to treat hypertension. Men and women aged 60 to 80 years will be recruited. To begin the study, systolic blood pressure must be less than 180 (top number) and diastolic blood pressure must be less than 110 (bottom number). Subjects in this study will be randomly assigned (similar to using a coin flip) to take either spironolactone (this medication blocks the effects of aldosterone) or hydrochlorothizide (a diuretic or water pill). This study is important because it will provide new information about the actions of aldosterone that may lead to increased blood pressure in older people, and the potential benefits of treating high blood pressure using an aldosterone blocking medication.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是确定肾上腺，醛固酮产生的激素的水平是否增加，醛固酮在血压的升高中起着常见的升高，随着人们的年龄增长。该研究旨在测试醛固酮与其他已知在老年人高血压中很重要的因素之间的相互作用。这些因素是血管的僵硬，交感神经系统的活性（神经系统的一部分，产生了控制心率和血压的化学去甲肾上腺素），胰岛素以及由血管产生的放松因子（一氧化氮）。这些系统将在研究开始时进行测试，并在用用于治疗高血压的两种药物之一治疗后六个月后再次测试。将招募60至80岁的男女。为了开始研究，收缩压必须小于180（最高数字），​​舒张压必须小于110（底数）。这项研究中的受试者将被随机分配（类似于使用硬币翻转），以服用螺内酯（这种药物阻止醛固酮的作用）或氢氯壳（利尿剂或水丸）。这项研究很重要，因为它将提供有关醛固酮作用的新信息，这可能导致老年人血压升高，以及使用醛固酮阻断药物治疗高血压的潜在益处。