PHENOMENOLOGY OF MAJOR DEPRESSION

重度抑郁症的现象学

• 批准号: 7374502
• 负责人: ERIK Bertil NELSON
• 金额: $ 4.61万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374502
• 关键词: PHENOMENOLOGY; MAJOR; DEPRESSION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies suggest that hypothalamic-pituitary-adrenal (HPA) axis dysregulation influences the presentation of depression related to specific groups of symptoms. A better understanding of the mechanisms underlying these differences could lead to novel targets for the treatment of depression, and help to explain variability among previous studies that typically included subjects with varying symptoms of depression. This study is designed to assess HPA activity and measures of acute stress responses in healthy volunteers and depressed patients as they relate to specific groups of symptoms. The hypothesis is that elevated HPA axis activity in depression is associated with insomnia, loss of appetite/weight loss, and anxiety, whereas low HPA activity is linked with fatigue, increased appetite/weight gain and lack of energy. Moreover, increased HPA activity, symptoms of insomnia, loss of appetite/weight loss and anxiety are hypothesized to correlate with a greater response to stress, whereas low HPA activity and symptoms of fatigue, increased appetite/weight gain and lack of energy are hypothesized to correlate with a decreased response to stress. These hypotheses will be tested by collection of stress hormones in the blood, urine and saliva during three separate conditions; baseline, following a diagnostic test using two FDA approved medications, and in response to a social stress test.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。研究表明，下丘脑 - 垂体 - 肾上腺（HPA）轴失调会影响与特定症状相关的抑郁症的表现。 更好地了解这些差异差异的机制可能会导致抑郁症治疗的新目标，并有助于解释以前的研究的可变性，这些研究通常包括抑郁症状症状不同的受试者。这项研究旨在评估健康志愿者和抑郁症患者急性应激反应的HPA活性和与特定症状组相关的抑郁症。假设是，抑郁症的HPA轴活动升高与失眠，食欲/体重减轻和焦虑有关，而低HPA活性与疲劳，食欲增加/体重增加和能量缺乏有关。此外，假设HPA活性增加，失眠症状，食欲/体重减轻和焦虑症是与对压力的更大反应相关的，而HPA活性低以及疲劳的症状，食欲/体重增加和能量缺乏，可以指出与压力减少压力相关。这些假设将通过在三个不同条件下的血液，尿液和唾液中收集压力激素来检验。基线，使用两种FDA批准的药物进行诊断测试，并响应社会压力测试。