DTC Advertising Effect on Adherence to Statin Therapy

DTC 广告对他汀类药物治疗依从性的影响

• 批准号: 7079438
• 负责人: W David Bradford
• 金额: $ 22.88万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7079438
• 关键词: advertising; antihypercholesterolemic agent; behavioral /social science research tag; blood disorder chemotherapy; clinical research; health science research analysis /evaluation; human data; hyperlipidemia; mass information media; therapy compliance

DESCRIPTION (provided by applicant): In August of 1997 the Food and Drug Administration (FDA) relaxed the rules governing broadcast advertising of prescription pharmaceutical products. Shortly thereafter, expenditures on direct to consumer advertising (DTCA) for prescription pharmaceuticals soared. This has lead to a great deal of debate in the medical profession and among health care insurers and managed care organizations. We propose to study one possible effect of DTCA - whether exposure to DTCA can improve patient adherence to prescribe pharmaceutical therapy (statins) for the treatment of hyperlipidemia. Adherence to therapy is known to be a barrier to effective care for many chronic diseases. Treatment with prescription statins has become a principal modality for managing hyperlipidemia. Several of the statins are among the most heavily advertised pharmaceuticals since 1997. We hypothesize that patients who are in areas where these drugs are heavily advertised will have better adherence to their prescription therapy than patients who live in areas where these drugs are not advertised, and as a consequence will have better outcomes. This proposal has four principle aims: 1) determine the degree to which DTCA affects physician patient populations; 2) determine the impact of DTCA on the likelihood that a patient is prescribed a lipid-lowering drug; 3) determine the impact of DTCA on adherence to therapy, given that a patient has a prescription; and 4) Determine the impact of DTCA on the effectiveness of prescription statin therapy. This study will utilize a unique research data base which combines detailed clinical information (from an extract of the electronic medical records of 65 geographically dispersed primary care practices) with detailed advertising data (brand, month, and media-market specific). A series of econometric models will be estimated to determine the adherence and health effects of DTCA.

描述（由申请人提供）：1997 年 8 月，食品和药物管理局 (FDA) 放宽了处方药品广播广告的规定。此后不久，处方药的直接消费者广告 (DTCA) 支出猛增。这在医学界、医疗保险公司和管理式医疗组织中引起了激烈的争论。我们建议研究 DTCA 的一种可能的影响 - 暴露于 DTCA 是否可以提高患者对治疗高脂血症的药物治疗（他汀类药物）的依从性。众所周知，坚持治疗是许多慢性病有效护理的障碍。处方他汀类药物治疗已成为治疗高脂血症的主要方式。有几种他汀类药物是自 1997 年以来广告最多的药物之一。我们假设居住在这些药物广告较多的地区的患者比居住在这些药物未做广告的地区的患者更能坚持处方治疗，并且因此会有更好的结果。该提案有四个主要目标： 1) 确定 DTCA 对医生患者群体的影响程度； 2) 确定 DTCA 对患者服用降脂药物的可能性的影响； 3) 在患者有处方的情况下，确定 DTCA 对治疗依从性的影响； 4) 确定 DTCA 对处方他汀类药物治疗效果的影响。这项研究将利用一个独特的研究数据库，该数据库结合了详细的临床信息（来自 65 个地理分散的初级保健机构的电子病历的摘录）和详细的广告数据（品牌、月份和媒体市场特定）。将评估一系列计量经济学模型以确定 DTCA 的依从性和健康影响。