WEIGHT LOSS INTERVENTION FOR SURVIVORS OF ER/PR NEGATIVE BREAST CANCER

针对 ER/PR 阴性乳腺癌幸存者的减肥干预

• 批准号: 7376702
• 负责人: MARA Z VITOLINS
• 金额: $ 4.91万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-17 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376702
• 关键词: beverages; breast neoplasms; health; weight loss

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies have found that being overweight is a risk factor for recurrence and death from breast cancer. A study conducted at Wake Forest found that body size (weight or Body Mass Index) was found to be associated with all breast cancer recurrence and was found to be more pronounced for women with estrogen and progesterone receptor negative [ER/PR (-)] tumors. Treatment of obesity by weight loss through changes of diet and physical activity decreases blood markers connected to increased breast cancer risk. Meal replacement beverages have been found helpful for women who are unable to change their eating habits to begin losing weight. We will use a soy-based meal replacement beverage because studies have shown that soy protein has cholesterol and bone health benefits. Offering ER/PR negative breast cancer survivors an intervention that potentially reduces their risk of recurrence that also carries with it the added benefits of improving their general health, lipid profiles, and perhaps their quality of life seems highly desirable.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。研究发现，超重是乳腺癌复发和死亡的危险因素。在韦克森林进行的一项研究发现，发现体型（体重或体重指数）与所有乳腺癌复发有关，并且发现对于雌激素和孕酮受体阴性女性[ER/PR（ - ）]肿瘤的女性更为明显。通过饮食和体育锻炼的变化通过体重减轻来治疗肥胖，降低了与乳腺癌增加的风险有关的血液标志物。已经发现替代饮料对无法改变饮食习惯而开始减肥的女性有帮助。我们将使用基于大豆的膳食替代饮料，因为研究表明大豆蛋白具有胆固醇和骨骼健康益处。提供ER/PR阴性乳腺癌幸存者一种干预措施，可能会降低其复发风险，这也带来了改善其一般健康，脂质概况以及他们的生活质量的额外好处。