TYPE 1 DIABETES GENETICS CONSORTIUM

1 型糖尿病遗传学联盟

• 批准号: 7379128
• 负责人: HENRY RODRIGUEZ
• 金额: $ 0.46万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379128
• 关键词: TYPE; DIABETES; GENETICS; CONSORTIUM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individual's risk for type 1 diabetes. The scientific objectives of the Type 1 Diabetes Genetics Consortium are: 1. To ascertain, study and establish a renewable source of DNA on 3000 "affected sib-pair" (ASP) families with at least two type 1 diabetic siblings, their parents, and +/- up to two non-diabetic siblings for studies to map genes that may be associated with type 1 diabetes; 2. To create a database for the scientific community that would facilitate the search for type 1 diabetes susceptibility genes; 3. To provide a centralized DNA repository to allow targeted studies of genetic structure and function for type 1 diabetes; 4. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy in the area of type 1 diabetes. To meet these objectives, the T1DGC will collect information and blood samples from sib-pair and trio families located in five study-defined geographic areas worldwide: Asia-Pacific, Europe, Latin America, North America, and the United Kingdom. The ultimate goal of this study is to provide the clinical and genetic resources to achieve the necessary sample size and sample availability for gene identification. The Consortium will establish a mechanism to ensure that scientists will work together toward a better understanding of the genetic factors that underlies risk for type 1 diabetes. The Consortium will gain a better understanding of disease mechanisms, with a purpose of altering these mechanisms and pathways in individuals at risk of type 1 diabetes.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。 1 型糖尿病遗传学联盟 (T1DGC) 将组织国际努力来识别决定个人患 1 型糖尿病风险的基因。 1 型糖尿病遗传学联盟的科学目标是： 1. 确定、研究和建立 3000 个“受影响的同胞对”(ASP) 家庭的可再生 DNA 来源，这些家庭至少有两个 1 型糖尿病兄弟姐妹、他们的父母以及+/- 最多两个非糖尿病兄弟姐妹进行研究，绘制可能与 1 型糖尿病相关的基因图谱； 2. 为科学界创建一个数据库，以方便寻找1型糖尿病易感基因； 3. 提供集中的DNA存储库，以便对1型糖尿病的基因结构和功能进行有针对性的研究； 4. 评估扩展研究成果的机会，以开发 1 型糖尿病领域的风险预测、预防和治疗方法。 为了实现这些目标，T1DGC 将从位于全球五个研究定义的地理区域的同胞对和三人家庭收集信息和血液样本：亚太地区、欧洲、拉丁美洲、北美和英国。 本研究的最终目标是提供临床和遗传资源，以实现基因鉴定所需的样本量和样本可用性。该联盟将建立一个机制，确保科学家共同努力，更好地了解导致 1 型糖尿病风险的遗传因素。该联盟将更好地了解疾病机制，目的是改变有 1 型糖尿病风险的个体的这些机制和途径。