SYSTEMIC ENDOTHELIAL CONSEQUENCES OF PERIODONTAL DISEASE

牙周疾病的全身内皮后果

• 批准号: 7379508
• 负责人: Salomon Amar
• 金额: $ 10.42万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379508
• 关键词: SYSTEMIC; ENDOTHELIAL; CONSEQUENCES; PERIODONTAL; DISEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodontal disease is a bacterial infection of the periodontal tissues that may lead to bone and tooth loss. When severe, the local infection in the mouth may stimulate release of factors into the blood that cause damage to blood vessels throughout the body. In support of this possibility, recent studies show that patients with periodontal disease have signs of damage to the endothelium (inner lining of cells in blood vessels). This effect might explain, in part, recent studies showing higher rates of heart attack and stroke in such patients. The proposed study will determine whether more intensive treatment of advanced periodontal disease (deep cleaning and gum surgery where appropriate) improves the function of the endothelium.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。牙周疾病是牙周组织的细菌感染，可能导致骨骼和牙齿脱落。严重时，口腔中的局部感染可能会刺激因血液释放到血液中损害整个体内血管的损害。为了支持这种可能性，最近的研究表明，牙周疾病患者对内皮（血管内细胞内衬）有损害的迹象。这种影响可能部分解释了最近的研究表明，此类患者的心脏病发作和中风率更高。拟议的研究将确定对晚期牙周疾病（在适当的情况下进行深层清洁和牙龈手术）的更深入治疗是否可以改善内皮的功能。