CYTOKINE/CHEMOKINE RESPONSE IN ASTHMA EXACERBATIONS DUE TO COLDS

感冒引起的哮喘加重中的细胞因子/趋化因子反应

• 批准号: 7375511
• 负责人: William W. Busse
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375511
• 关键词: CYTOKINE; CHEMOKINE; RESPONSE; ASTHMA; EXACERBATIONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many patients with asthma have worsening of asthma symptoms when they have an upper respiratory infection (head cold). Rhinovirus (RV), a common cold virus, is frequently linked with asthma exacerbations in children and young adults. This study looks at the why some individuals with asthma have worsening of their asthma when they get a cold and other individuals do not. Is it the type of virus or is the individual's reaction to any virus that causes the worsening of asthma symptoms. Research volunteers with asthma are asked to call the research unit when they develop a cold. Research samples including nasal washings, sputum (mucous coughed up from the lungs), blood, and in some cases, when safety allows, samples of fluid and tissue from the lungs are taken during the time when cold symptoms are present and then again when cold symptoms and asthma symptoms have returned to normal. We have found that there is a trend towards an increased frequency of asthma worsening in subjects who have a cold due to RV when compared to colds caused by viruses other than RV. Studies are ongoing to determine if this trend becomes more pronounced as we study more people. This study also looks at the reason that some individuals will have worsening of asthma symptoms with an RV cold while other individuals do not. We are focusing on a protein called interferon gamma (IFNg). Previous studies have indicated that individuals who make a low level of IFNg when exposed to RV tend to have greater worsening of asthma symptoms. Measurements of IFNg will also be made in this study to see if asthma exacerbations are associated with low levels of IFNg.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。许多哮喘患者在出现上呼吸道感染（感冒）时，哮喘症状会恶化。鼻病毒（RV）是一种普通感冒病毒，通常与儿童和年轻人的哮喘恶化有关。这项研究探讨了为什么一些哮喘患者在感冒时哮喘会恶化，而其他人则不会恶化。是病毒的类型还是个人对任何病毒的反应导致哮喘症状恶化。 患有哮喘的研究志愿者在感冒时需要给研究单位打电话。研究样本包括鼻腔冲洗液、痰液（从肺部咳出的粘液）、血液，在某些情况下，在安全允许的情况下，会在出现感冒症状时采集肺部液体和组织样本，然后在感冒时再次采集样本症状和哮喘症状已恢复正常。 我们发现，与由 RV 以外的病毒引起的感冒相比，由 RV 引起的感冒的受试者哮喘恶化的频率有增加的趋势。正在进行研究以确定随着我们研究更多人，这种趋势是否会变得更加明显。 这项研究还探讨了一些人因 RV 感冒而导致哮喘症状恶化而其他人则不会恶化的原因。我们关注的是一种称为γ干扰素（IFNg）的蛋白质。先前的研究表明，暴露于 RV 时产生低水平 IFNg 的个体往往会出现更严重的哮喘症状恶化。本研究还将进行 IFNg 测量，以了解哮喘恶化是否与 IFNg 水平低有关。