Self-Management of Type 1 Diabetes During Adolescence

青春期 1 型糖尿病的自我管理

• 批准号: 7149862
• 负责人: Dennis D Drotar
• 金额: $ 57.31万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7149862
• 关键词: adolescence (12-20); behavior prediction; behavioral /social science research tag; clinical research; family structure /dynamics; health behavior; human subject; insulin dependent diabetes mellitus; longitudinal human study; middle childhood (6-11); patient care management; patient oriented research; self help; therapy compliance

DESCRIPTION (provided by applicant): 240 young adolescents with Type 1 diabetes (DM1) will be studied in a three year prospective study that will include a comprehensive assessment of family and adolescent behavioral predictors and mediators of self- management, adherence to treatment, and DM1-related morbidity. The proposed study has the following specific aims: 1) to assess individual differences in patterns of self-management and adherence of DM1 from early to middle adolescence; 2) identify family and adolescent behavioral influences on change in self- management and adherence; and 3) to document the consequences of self-management and adherence on blood sugar control, hyperglycemic episodes, and health care utilization. In order to accomplish these aims, a model of family and adolescent influences on self-management and adherence will be tested using data analytic methods that characterize individual trajectories of self-management over time. The following hypotheses will be tested: 1) quality of family communication and family support of diabetes management and autonomy will influence adolescents' behavioral autonomy and autonomy with respect to DM1 self- management and adherence; 2) adolescents who demonstrate adaptive behavioral and diabetes-related autonomy and who are supported in their diabetes management by their parents will be more likely to develop effective, autonomous self-management and adherence; 3) adaptive self-management and adherence to DM1 treatment will enhance blood sugar control, reduce frequency of hypoglycemia, and health care utilization. The proposed study will generate important, clinically relevant scientific data concerning the causes and consequences of self-management of DM1 diabetes during early adolescence. Information from the proposed study will facilitate the development of preventive interventions to address problem patterns of DM1 self-management among young adolescents in order to lessen the deterioration in DM1-related treatment adherence and glycemic control that often occurs during adolescence. The development of targeted interventions based on data from the proposed study will have public health significance for enhancement of blood sugar control and reduction of DM1 related morbidity in adolescents and young adults.

描述（由申请人提供）：将在一项为期三年的前瞻性研究中对 240 名患有 1 型糖尿病 (DM1) 的青少年进行研究，该研究将包括对家庭和青少年行为预测因素以及自我管理、治疗依从性和自我管理调节因素的综合评估。 DM1 相关发病率。拟议的研究有以下具体目的：1）评估青春期早期到中期自我管理模式和 DM1 依从性的个体差异； 2）确定家庭和青少年行为对自我管理和依从性变化的影响； 3) 记录自我管理和坚持对血糖控制、高血糖发作和医疗保健利用的影响。为了实现这些目标，将使用数据分析方法来测试家庭和青少年对自我管理和依从性的影响模型，该方法描述了随着时间的推移自我管理的个人轨迹。将检验以下假设：1）家庭沟通质量以及家庭对糖尿病管理和自主的支持将影响青少年在DM1自我管理和依从方面的行为自主和自主； 2）表现出适应性行为和糖尿病相关自主性并且在糖尿病管理方面得到父母支持的青少年将更有可能发展有效、自主的自我管理和依从性； 3）适应性自我管理和坚持DM1治疗将增强血糖控制，减少低血糖频率和医疗保健利用率。拟议的研究将产生有关青春期早期 DM1 糖尿病自我管理的原因和后果的重要的、临床相关的科学数据。拟议研究的信息将有助于制定预防性干预措施，以解决青少年中 DM1 自我管理的问题模式，从而减轻青春期经常发生的 DM1 相关治疗依从性和血糖控制的恶化。根据拟议研究的数据制定有针对性的干预措施对于加强青少年和年轻人的血糖控制和减少 DM1 相关发病率具有公共卫生意义。