Genetics of coordinately evolving patterns and behavior

协调进化模式和行为的遗传学

• 批准号: 7391167
• 负责人: JOHN R TRUE
• 金额: $ 22.74万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391167
• 关键词: Accounting; Address; Alleles; Architecture; Asians; Behavior; Behavioral; Biological Markers; Candidate Disease Gene; Chromosome Mapping; Color; Complex; Courtship; Cues; Data; Development; Disease; Drosophila genus; Evolution; Female; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genome; Goals; Hand; Human; Human Development; Knowledge; Link; Maps; Modeling; Molecular Genetics; Morphology; Nature; Numbers; Pathway interactions; Pattern; Phenotype; Pigmentation physiologic function; Pigments; Positioning Attribute; Quantitative Trait Loci; Recording of previous events; Research; Research Personnel; Signal Transduction; Spottings; Taxon; Testing; Thinking; Variant; Wing; Work; base; design; insight; interest; male; pleiotropism; programs; response; sex; species difference; trait

DESCRIPTION (provided by applicant): The genetic architecture underlying natural variation in complex trait assemblages is not well understood. Elucidating this architecture could contribute greatly to our knowledge of the mechanisms promoting developmental and behavioral diversity and novelty, as well as provide models for understanding genetically based variation in complex human traits. The proposed project aims to develop linkage and QTL maps in the Drosophila elegans/gunungcola species pair to determine the molecular genetic basis of intra- and interspecies variation in body color and interspecies divergence in two male-specific traits, wing spots and wing courtship display, that are tightly evolutionarily associated. Specifically, this work is designed to address three longstanding questions on the origins and dynamics of morphogenetic and behavioral diversity. First, deciphering the genetics of pigmentation and behavioral divergence in these species will provide important insights on the types of loci and alleles underlying the responses of morphogenetic and behavioral pathways to natural and sexual selection. Second, mapping the positions of quantitative trait loci (QTLs) for each trait will help to reveal whether the genetic architectures of evolutionarily associated traits are independent or connected by linkage or pleiotropy. Third, comparing the genetic basis of body color variation within and between species will indicate whether the mechanisms underlying between-species divergence are similar to or distinct from those underlying within-species polymorphism, thus testing a main tenet of the neo-Darwinian evolutionary synthesis. These questions are also of great interest to developmental and behavioral biologists, who seek to determine the molecular genetic basis of complex, species-specific phenotypes and whether genetic information from model species can be applied across taxa. Because evolutionary change in male wing pigment patterns and display behaviors has occurred repeatedly in the Oriental melanogaster group lineages, our results will also enable us to investigate whether independent cases of pigmentation and courtship evolution involve similar or distinct genetic underpinnings.

描述（由申请人提供）：复杂性状组合中自然变异的遗传结构尚不清楚。阐明这种结构可以极大地促进我们对促进发育和行为多样性和新颖性的机制的了解，并为理解复杂人类特征中基于遗传的变异提供模型。拟议项目旨在开发线虫/古农可乐物种对中的连锁和 QTL 图谱，以确定体色的种内和种间变异以及两种雄性特异性特征、翅斑和翅求偶展示的种间差异的分子遗传基础，是在进化上紧密相关的。具体来说，这项工作旨在解决关于形态发生和行为多样性的起源和动态的三个长期存在的问题。首先，破译这些物种的色素沉着和行为差异的遗传学将为了解形态发生和行为途径对自然和性选择的反应背后的基因座和等位基因类型提供重要的见解。其次，绘制每个性状的数量性状基因座（QTL）的位置将有助于揭示进化相关性状的遗传结构是独立的还是通过连锁或多效性连接。第三，比较物种内和物种间体色变异的遗传基础，将表明物种间差异的机制与物种内多态性的机制是否相似或不同，从而检验新达尔文进化综合的主要原理。这些问题也引起了发育和行为生物学家的极大兴趣，他们试图确定复杂的、物种特异性表型的分子遗传基础，以及来自模型物种的遗传信息是否可以应用于跨类群。由于雄性翅膀色素模式和展示行为的进化变化在东方黑腹果蝇群体谱系中反复发生，因此我们的结果也将使我们能够调查色素沉着和求偶进化的独立案例是否涉及相似或不同的遗传基础。