Core--Scientific

核心--科学

• 批准号: 7150291
• 负责人: ARDYTHE L MORROW
• 金额: $ 14.64万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7150291
• 关键词: biomedical facility; computer data analysis; cooperative study; data management; epithelium; experimental designs; functional /structural genomics; genetic polymorphism; genetic susceptibility; genotype; hypersensitivity; statistics /biometry

The purpose of the Genetic/Genomic Data Analysis core is to provide the capacity to rigorously and efficiently address the overall hypothesis and goals of the proposed Center and its individual projects through state of the art approaches to quantitative genetics, genomics, health outcomes and integrated systems biology. The overall hypothesis of this application is that epithelial cell genes play a central role in the pathogenesis and successful treatment of allergic disorders; each of the projects has specific aims that address different aspects of this overall hypothesis. The aims of this Core are thus to: 1) provide study design, data management, and analysis support to the project investigators to fulfill their specific aims; 2) integrate data collected in the individual projects and thereby further interactions among projects on the role of epithelial genes in allergic inflammation; and 3) promote additional analyses and investigations that support the central theme and overall goals of this center. To fulfill these aims, this core includes an experienced set of faculty and staff with recognized expertise in statistical analysis, epidemiology, quantitative genetics, genomics, bioinformatics, and data management. Core investigators will meet routinely with each other, and with project investigators as needed. The PI of this core will meet routinely with project leadership to maintain accountability and prioritize the research support of the core. The primary projects described in this application involve analysis of samples and data derived from case-control and family studies that are based on large and growing registries of children seen at Cincinnati Children's with allergic disorders. These projects will require application of analytic methods appropriate for genetic epidemiology and microarray studies, including univariate comparisons and multivariable modelling to account for multiple genes and/or environmental factors as appropriate. The core will also support analysis of an extant population-based cohort of asthmatic children to test the replication of findings of the asthma case-control study conducted in project by Khurana.

遗传/基因组数据分析核心的目的是提供严格的能力和 有效解决拟议中心及其个别项目的总体假设和目标 通过最终的遗传学，基因组学，健康结果和综合的方法 系统生物学。该应用的总体假设是上皮细胞基因在 发病机理和成功治疗过敏性疾病；每个项目都有具体的目的 解决这一总体假设的不同方面。因此，该核心的目的是：1）提供研究 为项目调查人员设计，数据管理和分析支持，以实现其具体目标； 2） 整合在各个项目中收集的数据，从而在项目之间进行进一步的互动 在过敏性炎症中上皮基因； 3）促进其他分析和调查 支持该中心的中心主题和整体目标。为了实现这些目标，该核心包括 经验丰富的教职员工以及在统计分析，流行病学方面具有公认的专业知识， 定量遗传学，基因组学，生物信息学和数据管理。核心调查人员将定期见面 彼此之间，并根据需要与项目调查人员一起。该核心的PI将与项目定期相遇 领导才能保持问责制并确定核心的研究支持。主要项目 在此应用中所描述的涉及分析样本和来自病例对照和家庭的数据 基于在辛辛那提儿童中看到的大型且不断增长的儿童注册表的研究 疾病。这些项目将需要应用适合遗传流行病学的分析方法 和微阵列研究，包括单变量比较和多变量建模，以说明多个 基因和/或环境因素适当。核心还将支持现存的分析 基于人群的哮喘儿童队列测试哮喘病例对照发现的复制 Khurana在项目中进行的研究。